Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine

0135983 - ENTU-I 20033006 RIV US eng J - Journal Article
Žurovec, Michal - Doležal, Tomáš - Gaži, Michal - Pavlová, Eva - Bryant, P. J.
Adenosine deaminase-related growth factors stimulate cell proliferation in Drosophila by depleting extracellular adenosine.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 99, č. 7 (2002), s. 4403-4408. ISSN 0027-8424. E-ISSN 1091-6490
R&D Projects: GA ČR GA204/01/1022; GA AV ČR IAA5007107
Institutional research plan: CEZ:AV0Z5007907
Keywords : adenosine daminase * minimal medium
Subject RIV: CE - Biochemistry
Impact factor: 10.701, year: 2002

We describe a protein family in Drosophila containing six adenosine deaminase-related growth factors (ADGFs), which are homologous to a mitogenic growth factor discovered in conditioned medium from cells of a different fly species, Sarcophaga. Closely related proteins have been identified in other animals, and a human homolog is implicated in the genetic disease Cat-Eye Syndrome. The two most abundantly expressed ADGFs in Drosophila larvae are ADGF-A, which is strongly expressed in the gut and lymph glands, and ADGF-D, which is mainly expressed in the fat body and brain. Recombinant ADGF-A and ADGF-D are active adenosine deaminases (ADAs), and they cause polarization and serum-independent proliferation of imaginal disk and embryonic cells in vitro. The enzymatic activity of these proteins is required for their mitogenic function, making them unique among growth factors.
Permanent Link: http://hdl.handle.net/11104/0033752