Insect silk contains protease inhibitors

0135761 - ENTU-I 20010187 SIGLE CZ eng A - Abstract
Kodrík, Dalibor - Nirmala, Xavier
Insect silk contains protease inhibitors.
Physiological Research. Fyziologický ústav AV ČR, v. v. i. Roč. 50, - (2001), s. 12. ISSN 0862-8408. E-ISSN 1802-9973.
[Fyziologické dny /77./. 07.02.2001-09.02.2001, České Budějovice]
Institutional research plan: CEZ:AV0Z5007907
Subject RIV: CE - Biochemistry

We demonstrated that two of the small peptides proesent in the silk of the waxmoth, Galleria mellonella , inhibit proteolytic enzymes, and are thus called sild proteinase inhibitors 1 and 2 (SPI 1, SPI 2). They are produced in the middle section of the silk-secreting glands prior to cocoon spinning and their production is controlled at the transcription level. The SPI 1 (6056.7 Da, 56 residues) is a typical thermostable Kunitz-type proeinase inhibitor while the SPI 2 (3993 Da, 36 residues) is a single-domain Kazal-type proteinase inhibitor with unique structural features 291 lepidopteran silk
Permanent Link: http://hdl.handle.net/11104/0033540