Elevation of extracellular adenosine mobilizes haematopoietic progenitor cells and granulocytes into peripheral blood and enhances the mobilizing effects of granulocyte colony-stimulating factor

0127056 - BFU-R 20033144 RIV CZ eng J - Journal Article
Hofer, Michal - Weiterová, Lenka - Vacek, Antonín - Znojil, V. - Pospíšil, Milan - Vácha, J.
Elevation of extracellular adenosine mobilizes haematopoietic progenitor cells and granulocytes into peripheral blood and enhances the mobilizing effects of granulocyte colony-stimulating factor.
European Journal of Haematology. Roč. 71, č. 3 (2003), s. 204-210. ISSN 0902-4441. E-ISSN 1600-0609
R&D Projects: GA ČR GA305/02/0423; GA AV ČR IBS5004009; GA AV ČR KSK5011112
Institutional research plan: CEZ:AV0Z5004920
Keywords : extracellular adenosine * dipyridamole * adenosine monophosphate
Subject RIV: BO - Biophysics
Impact factor: 1.714, year: 2003

We tested the capabilities of drugs elevating extracellular adenosine and of granulocyte colony-stimulating factor (G-CSF), given alone or in combination, to mobilize haematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) and granulocytes into peripheral blood. Elevation of extracellular adenosine was induced by joint administration of dipyridamole (DP), a drug inhibiting the cellular uptake of adenosine, and adenosine monophosphate ( AMP) serving as an adenosine prodrug. DP + AMP, G-CSF or all these drugs in combination were administered either singly or repeatedly in a 4-d treatment regimen. Elevation of extracellular adenosine was found to mobilize significantly both GM-CFC and granulocytes after both single and repeated administration of DP + AMP. These results show that the elevation of extracellular adenosine presents a potent mechanism for mobilization of GM-CFC and granulocytes into the blood.
Permanent Link: http://hdl.handle.net/11104/0025279