Differential effects of v-Jun and c-Jun proteins on v-myb-transformed monoblasts

0126862 - BFU-R 20023162 RIV CH eng J - Journal Article
Ševčíková, S. - Souček, Karel - Kubala, Lukáš - Bryja, Vítězslav - Šmarda, J.
Differential effects of v-Jun and c-Jun proteins on v-myb-transformed monoblasts.
Cellular and Molecular Life Sciences. Roč. 59, č. 10 (2002), s. 1690-1705. ISSN 1420-682X. E-ISSN 1420-9071
R&D Projects: GA ČR GA301/01/0040
Institutional research plan: CEZ:AV0Z5004920
Keywords : v-myb * Jun * differentiation
Subject RIV: BO - Biophysics
Impact factor: 5.259, year: 2002

We ectopically expressed v-jun and c-jun in BM2 cells and evaluated their effects on differentiation and proliferation. c-Jun up-regulated the transactivation activity of v-Myb and induced a proliferation block and differentiation of BM2 cells. In contrast, v-Jun downregulated v-Myb transactivation causing no dramatic effects on BM2 cells. Both c-Jun and v-Jun proteins affected sensitivity of BM2 cells to retinoic acid and phorbol ster. These data suggest that Jun plays a major role in macrophage differentiation.
Permanent Link: http://hdl.handle.net/11104/0025089