Inhibition of gap junctional intercellular communication by polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action

0126818 - BFU-R 20023118 RIV CZ eng C - Conference Paper (international conference)
Bláha, L. - Vondráček, Jan - Upham, B. L. - Machala, M.
Inhibition of gap junctional intercellular communication by polychlorinated biphenyls: inhibitory potencies and screening for potential mode(s) of action.
SECOTOX 2002. Regional Meeting of the Central and Eastern European Section /7./ Book of Abstracts. Brno: Masarykova univerzita, 2002, s. 155-158.
[SECOTOX 2002. Regional Meeting of the Central and Eastern European Section /7./. Brno (CZ), 14.10.2002-16.10.2002]
R&D Projects: GA MZe QC0194; GA ČR GA525/00/D101
Keywords : PCBs * GJIC inhibition * tumor promotion
Subject RIV: BO - Biophysics

The aims of the present study were to determine potencies of a series of environmentally relevant PCB congeners to inhibit GJIC invitro, and to screen for intrcellular signaling pathways potentially involved in GJIC downregulation by PCBs. It was found that a number of nonplanar PCB congeners are efficient inhibitors of GJIC in vitro, and that a model compound, PCB153, does not act via activation of PKC or ERK1/2, which is contrast with the effects of protoypical inhibitors of GJIC, such as TPA or EGF.
Permanent Link: http://hdl.handle.net/11104/0025046