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Nuclear structure and gene activity in human differentiated cells
- 1.0126775 - BFU-R 20023074 RIV US eng J - Journal Article
Bártová, Eva - Kozubek, Stanislav - Jirsová, Pavla - Kozubek, Michal - Gajová, H. - Lukášová, Emilie - Skalníková, M. - Cafourková, Alena - Koutná, I. - Hausmann, M.
Nuclear structure and gene activity in human differentiated cells.
Journal of Structural Biology. Roč. 139, č. 2 (2002), s. 76-89. ISSN 1047-8477. E-ISSN 1095-8657
R&D Projects: GA AV ČR IBS5004010; GA AV ČR IAB5004102; GA ČR GA301/01/0186
Institutional research plan: CEZ:AV0Z5004920
Keywords : nuclear compartments * gene expression * FISH
Subject RIV: BO - Biophysics
Impact factor: 4.194, year: 2002
The nuclear arrangement and activity of the ABL, c-MYC, and RB1 genes was quantitatively investigated in human undifferentiated HL-60 cells and in a terminally differentiated population of human granulocytes. In the experiments presented here, we provide evidence that the regulation of gene activity during important cellular processes such as differentiation or carcinogenesis may be realised through heterochromatin-mediated gene silencing.
Permanent Link: http://hdl.handle.net/11104/0025003
Number of the records: 1