Impedance analysis of DNA and DNA-drug interactions on thin mercury film electrodes

0126753 - BFU-R 20023052 RIV US eng J - Journal Article
Hasoň, Stanislav - Dvořák, Jakub - Jelen, František - Vetterl, Vladimír
Impedance analysis of DNA and DNA-drug interactions on thin mercury film electrodes.
Critical Reviews in Analytical Chemistry. Roč. 32, č. 2 (2002), s. 167-179. ISSN 1040-8347. E-ISSN 1547-6510
R&D Projects: GA AV ČR IAA4004901; GA AV ČR IAA4004002; GA AV ČR IBS5004107
Grant - others:GA FRVŠ(XC) G40583; GA FRVŠ(XC) F40564
Institutional research plan: CEZ:AV0Z5004920
Keywords : electrochemical impedance spectroscopy * intercalators * DNA at electrode surface
Subject RIV: BO - Biophysics
Impact factor: 2.074, year: 2002

In this review we briefly summarize the results of impedance measurements (dependence of the differential capacitance C and/or impedance Z of the electrode double layer on potential E, C-E curves) or on frequency (Electrochemical Impedance Spectroscopy-EIS) of nucleic acids at mercury film electrode (MFE). Mercury film was plated either on a glassy carbon electrode (GCE) or pyrolytic graphite electrode (PGE). The dependence of the pseudocapacitance redox peak of echinomycin on concentration and on the ac voltage frequency was measured in bulk solution. Interaction of single- and double-stranded DNA with bis-intercalator echinomycin at nucleic acid-modified surface was studied using EIS with adsorptive transfer method.
Permanent Link: http://hdl.handle.net/11104/0024981