Number of the records: 1
Modulation of death receptor-mediated apoptosis in differentiating human myeloid leukemia HL-60 cells
- 1.0126491 - BFU-R 20013051 RIV US eng J - Journal Article
Vondráček, Jan - Sheard, M. A. - Krejčí, P. - Minksová, Kateřina - Hofmanová, Jiřina - Kozubík, Alois
Modulation of death receptor-mediated apoptosis in differentiating human myeloid leukemia HL-60 cells.
Journal of Leukocyte Biology. Roč. 69, č. 5 (2001), s. 794-802. ISSN 0741-5400. E-ISSN 1938-3673
R&D Projects: GA ČR GA312/98/P011; GA ČR GA524/99/0694
Institutional research plan: CEZ:AV0Z5004920
Keywords : all-trans retinoic acid * dimethyl sulfoxide
Subject RIV: BO - Biophysics
Impact factor: 4.516, year: 2001
Cellular differentiation can play an important role in cell sensitivity to apoptotic stimuli. In the present study, effects of dimethyl sulfoxide (DMSO)- and all-trans retinoic acid (ATRA)-induced differentiation on tumor necrosis factor-alpha (TNF-alpha)- and anti-Fas-induced apoptosis in human myeloid leukemia cell line were studied. It was shown that DMSO potentiates, while ATRA blocks TNF-alpha and anti-Fas-induced apoptosis, in a time dependent manner
Permanent Link: http://hdl.handle.net/11104/0024719
Number of the records: 1