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Adsorptive Transfer Stripping AC Voltammetry of DNA Complexes with Intercalators
- 1.0126373 - BFU-R 20000191 RIV US eng J - Journal Article
Fojta, Miroslav - Havran, Luděk - Fulnečková, Jana - Kubičárová, Tatiana
Adsorptive Transfer Stripping AC Voltammetry of DNA Complexes with Intercalators.
Electroanalysis. Roč. 12, č. 12 (2000), s. 926-934. ISSN 1040-0397. E-ISSN 1521-4109
R&D Projects: GA AV ČR IAA4004801; GA ČR GA204/98/P091; GA ČR GV204/97/K084
Institutional research plan: CEZ:AV0Z5004920
Subject RIV: BO - Biophysics
Impact factor: 1.972, year: 2000
Using alternating current adsorptive transfer stripping voltammetry at hanging mercury drop electrode, conformational changes of DNA due to binding of DNA intercalators were studied. After medium exchange and intercalator removal, the surface-confined DNA probably adopted a restrained structure which was resistent to DNA surface denaturation. Upon introduction of DNA single-strand breaks, the specific behavior of DNA-intercalator complexes was eliminated.
Permanent Link: http://hdl.handle.net/11104/0024603
Number of the records: 1