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Development of the inner ear in Splotch mutant mice
- 1.0109646 - UEM-P 20043043 RIV US eng J - Journal Article
Buckiová, Daniela - Syka, Josef
Development of the inner ear in Splotch mutant mice.
[Vývoj vnitřního ucha u mutantních myší Splotch.]
Neuroreport. Roč. 15, č. 13 (2004), s. 2001-2005. ISSN 0959-4965. E-ISSN 1473-558X
R&D Projects: GA ČR GA309/04/1074; GA MZd NR8113
Institutional research plan: CEZ:AV0Z5039906
Keywords : inner ear * Pax-3
Subject RIV: FF - HEENT, Dentistry
Impact factor: 2.351, year: 2004
We show that the homozygous Splotch mutation (Sp(2H)) is associated with severe defects that prevent the formation of the cochlea and vestibulo-cochlear ganglion.During the period of vestibular and cochlear ganglia formation, PSA NCAM expression was decreased. The expression of calcium binding proteins (S100) in the vestibulo-cochlear ganglion was also decreased
Studie ukázala, že u homozygotní mutace Splotch (Sp(2H) je defektivní formace hlemýždě a vestibulo-kochleárního ganglia. V období vývoje vestibulo- kochleárního ganglia zde byla prokázano snížení exprese PSA NCAM a proteinů važících vápník (S100)
Permanent Link: http://hdl.handle.net/11104/0016754
Number of the records: 1