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Feedback-resistant acetohydroxy acid synthase increases valine production in Corynebacterium glutamicum
- 1.0108089 - MBU-M 20049294 RIV US eng J - Journal Article
Elišáková, Veronika - Pátek, Miroslav - Holátko, Jiří - Nešvera, Jan - Leyval, D. - Goergen, J.-L. - Delaunay, S.
Feedback-resistant acetohydroxy acid synthase increases valine production in Corynebacterium glutamicum.
[Synthasa acetohydroxykyselin, rezistentní k inhibici zpětnou vazbou, zvyšuje produkci valinu u Corynebacterium glutamicum.]
Applied and Environmental Microbiology. Roč. 71, č. 1 (2005), s. 207-213. ISSN 0099-2240. E-ISSN 1098-5336
R&D Projects: GA ČR GA525/01/0916; GA ČR GA525/04/0548
Grant - others:VALPAN(XE) QLK3-2000-00497
Institutional research plan: CEZ:AV0Z5020903
Keywords : corynebacterium glutamicum * ahas
Subject RIV: EE - Microbiology, Virology
Impact factor: 3.818, year: 2005
Mutation in the regulatory subunit of acetohydroxy acid synthase from Corynebacterium glutamicum, the key enzyme of biosynthesis of brached-chain amino acids, resulted in feedback resistant enzyme. The strains carrying this mutation in the chromosome produced more valine than their wild-type counterparts.
Mutace v regulační podjednotce synthasy acetohydroxykyselin z Corynebacterium glutamicum (klíčový enzym biosyntézy větvených aminokyselin) vedla k enzymu rezistentnímu k inhibici zpětnou vazbou. Kmeny s touto mutací v chromosomu produkovaly více valinu než původní kmen.
Permanent Link: http://hdl.handle.net/11104/0015228
Number of the records: 1