Changes of TDGA Concentration in Human Urine as Possible Marker of Metabolism of Thiocompounds

0107585 - UFCH-W 20040163 RIV CZ eng C - Conference Paper (international conference)
Přistoupilová, K. - Přistoupil, T. I. - Šenholdová, Z. - Navrátil, Tomáš - Heyrovský, Michael - Fenclová, Z.
Changes of TDGA Concentration in Human Urine as Possible Marker of Metabolism of Thiocompounds.
[Změny koncentrace TDGA v moči jako možný marker metabolismu thiosloučenin.]
Atherosklerosa 2004. Praha: ČVUT, 2004, s. 106-111. ISBN 80-239-3523-2.
[Atherosklerosa. Praha (CZ), 15.09.2004-17.09.2004]
Institutional research plan: CEZ:AV0Z4040901
Keywords : thiodiglycolic acid (TDGA) * homocysteine * voltammetry
Subject RIV: CE - Biochemistry

The new simple voltammetric method we described recently, proved already to be useful in determining thiodiglycolic acid (TDGA) levels in urine samples of people influenced by some chemicals, victuals and pharmaceuticals. The present pilot study is a continuation of our previous work devoted to test general feasibility of the method. We concentrated upon time dependent quantitative changes of TDGA excretion into urine of selected volunteers. The TDGA level in all morning samples was the highest in comparison with samples collected during the day. The TDGA level was dependent on the health condition of each person involved. However, a further marked increase of TDGA in the morning urine was observed individually, in general when vitamin B12 had been administered in the evening the day before. Vitamin B12 is known to play an important role in the metabolism of one- and two-carbon units, of homocysteine and of sulfhydryls in general. Certain differences in excretion course of TDGA.

Je popisována nová, rychlá, levná, jednoduchá voltametrická metoda stanovení kyseliny thiodiglykolové (TDGA). Tato látka představuje jeden z metabolitů S-karboxymethylcysteinu a je vylučována močí. Tato kyselina je jednou z mnoha detoxikačních cest lidského organismu.
Permanent Link: http://hdl.handle.net/11104/0014739