0102869 - UOCHB-X 20043335 RIV AT eng J - Journal Article
Hlaváček, Jan - Mařík, Jan - Konvalinka, Jan - Bennettová, Blanka - Tykva, Richard
Synthesis and application of methyleneoxy pseudodipeptide building blocks in biologically active peptides.
[Syntéza a uplatnění methylenoxy pseudodipeptidových stavebních bloků v biologicky aktivních peptidech.]
Amino Acids. Roč. 27, - (2004), s. 19-27. ISSN 0939-4451. E-ISSN 1438-2199
R&D Projects: GA ČR GA203/98/1330; GA ČR GA203/02/0247
Institutional research plan: CEZ:AV0Z4055905
Keywords : methyleneoxy isoster * HIV protease inhibitor * oostatic activity
Subject RIV: CC - Organic Chemistry
Impact factor: 2.000, year: 2004

Pseudopeptides H-Phe psi[CH2O]Phe-OH, H-Tyr psi[CH2O] Asp-OH and H-Pro psi[CH2O]-D-Thr-OH were synthesized using the intramolecular Williamson reaction. Synthesized pseudodipeptides were introduced into HIV protease inhibitors and into peptides with oostatic activity

Pseudopeptidy H-Phe psi[CH2O]Phe-OH, H-Tyr psi[CH2O] Asp-OH and H-Pro psi[CH2O]-D-Thr-OH byly syntetizovány s využitím intramolekulární Williamsonovy reakce. Syntetizované pseudodipeptidy byly zavedeny do inhibitorů HIV proteasy a do peptidů s oostatickou aktivitou
Permanent Link: http://hdl.handle.net/11104/0010206