Intramolecular stacking interactions in ternary copper(II) complexes formed by a heteroaromatic amine and 9-[2-(2-phosphonoethoxy)ethyl]adenine, a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine

0101971 - UOCHB-X 20043235 RIV US eng J - Journal Article
Fernández-Botello, A. - Holý, Antonín - Moreno, V. - Sigel, H.
Intramolecular stacking interactions in ternary copper(II) complexes formed by a heteroaromatic amine and 9-[2-(2-phosphonoethoxy)ethyl]adenine, a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine.
[Komplexy dvojmocné mědi s hetroaromatickým aminem a PEEA, analogu antivirotika PMEA.]
Journal of Inorganic Biochemistry. Roč. 98, - (2004), s. 2114-2124. ISSN 0162-0134. E-ISSN 1873-3344
R&D Projects: GA MŠMT OC D20.002
Institutional research plan: CEZ:AV0Z4055905
Keywords : adenine nucleotide analogues * intramolecular equilibria * isomeric complexes
Subject RIV: CC - Organic Chemistry
Impact factor: 2.225, year: 2004

The stability constants of the mixed-ligand complexes formed between Cu(Arm)2+, where Arm phenanthroline (Phen), and the dianions of 9-[2-(2-phosphonoethoxy)ethyl]adenine (PEEA2-) and [2-(2-ethoxy)ethyl]phosphonate, were determined. The increased stability is attributed to intramolecular stack formation in the residue of PEEA 2-. Conclusions regarding the antiviral properties of several acyclic nucleoside phosphonates are discussed

Byly stanoveny konstanty stability komplexu iontů mědi s dianiontem PEEA a aromatickými .aminy. zvýšená stabilita vůči odpovídajícím komplexům PMEA se vysvětluje intramolekulárním stackingem
Permanent Link: http://hdl.handle.net/11104/0009336