0101287 - UMCH-V 20043007 RIV CZ eng C - Conference Paper (international conference)
Etrych, Tomáš - Chytil, Petr - Strohalm, Jiří - Jelínková, Markéta - Kovář, Marek - Říhová, Blanka - Ulbrich, Karel
Polymer anticancer drugs with pH- and enzyme-dependent activation.
[Polymerní protirakovinná léčiva s pH- a enzymaticky závislou aktivací.]
Proceedings. České Budějovice: Department of Structure and Function of Proteins, Institute of Physical Biology, University of South Bohemia, 2004, s. 15.
[Nové Hrady Winter Symposium on Structure and Function of Proteins /1./. Nové Hrady (CZ), 22.01.2004-24.01.2004]
R&D Projects: GA ČR GA305/02/1425
Institutional research plan: CEZ:AV0Z4050913
Keywords : targetable drug delivery system * copolymers of N-(2-hydroxypropyl)methacrylamide * pH-sensitive bond
Subject RIV: CD - Macromolecular Chemistry

Water-soluble synthetic polymers and their conjugates with antibodies, oligopeptides or saccharides proved a potential targetable drug delivery system. Recently, copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) have been developed in our laboratory as polymeric carriers of drugs.

Vodorozpustné syntetické polymery a jejich konjugáty s protilátkami, oligopeptidy nebo sacharidy jsou potenciálními systémy pro cílený transport léčiv. V poslední době byly k tomuto účelu v naší laboratoři vyvinuty kopolymery N-(2-hydroxypropyl)methakrylamidu.
Permanent Link: http://hdl.handle.net/11104/0008721