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Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2)

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    0100996 - UEM-P 20043025 RIV US eng J - Journal Article
    Iacovelli, L. - Capobianco, L. - Iula, M. - Di Giorgi Gereviny, V. - Picascia, A. - Blahoš, Jaroslav - Melchiorri, D. - Nicoletti, F. - De Blasi, A.
    Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2).
    [Regulace mGluR4 metabotropního glutamátového receptoru typem 2 G-protein spřažené kinázy GRK2.]
    Molecular Pharmacology. Roč. 65, č. 5 (2004), s. 1103-1110. ISSN 0026-895X. E-ISSN 1521-0111
    Institutional research plan: CEZ:AV0Z5039906
    Keywords : glutamate receptor
    Subject RIV: FR - Pharmacology ; Medidal Chemistry
    Impact factor: 5.080, year: 2004

    We examined the role of G-protein coupled receptor kinase-2 (GRK2) in the homologous desensitization of mGlu4 metabotropic glutamate receptors transiently expressed in human embryonic kidney (HEK) 293 cells. Receptor activation with agonist stimulated at least two distinct signaling pathways: inhibition of cAMP formation and activation of the mitogen-activated protein kinase (MAPK) pathway.

    V našich experimentech jsme zkoumali roli GRK2 v homologní desentizaci Mglu4. Zjistili jsme že aktivace receptoru stimuluje nejméně dvě různé signální kaskády“ cAMP a MAPK
    Permanent Link: http://hdl.handle.net/11104/0008471


     
     
Number of the records: 1  

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