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Photophysical properties of porphyrinoid sensitizers non-covalently bound to host molecules; models for photodynamic therapy
- 1.0100767 - UACH-T 20043014 RIV CH eng J - Journal Article
Lang, Kamil - Mosinger, Jiří - Wagnerová, Dana Marie
Photophysical properties of porphyrinoid sensitizers non-covalently bound to host molecules; models for photodynamic therapy.
[Fotofizikální vlastnosti porfirinoidních senzitizátorů nekovalentně vázaných host molekuly; modely pro fotodynamickou terapii.]
Coordination Chemistry Reviews. Roč. 248, 3-4 (2004), s. 321-350. ISSN 0010-8545. E-ISSN 1873-3840
R&D Projects: GA ČR GA203/01/0634; GA ČR GA203/02/0420; GA ČR GA203/02/1483
Institutional research plan: CEZ:AV0Z4032918
Keywords : non-covalent binding * porphyrin * excited states
Subject RIV: CA - Inorganic Chemistry
Impact factor: 6.446, year: 2004
The binding of photosensitizers to host molecules is discussed from the perspective of how the confinement in a molecular assembly influences the sensitizer's photophysical properties. In connection with photodynamic therapy (PDT) of cancer during which the administered sensitizer necessarily interacts with the biological material the problem becomes of utmost importance. This review surveys changes of photophysical behaviour of porphyrins, metalloporphyrins and other porphyrinoid sensitizers induced by their interaction with biopolymers (proteins, nucleic acids), liposomes or synthetic sensitizer carriers (cyclodextrins, calixarenes). The structure, charge, and physicochemical properties of the sensitizer predetermine the type of interaction with the surrounding microenvironment and are manifested by changes in absorption, fluorescence, kinetics of deactivation of the excited states, and generation of singlet oxygen. As follows from the collected data, binding of the sensitizer does not restrict formation of the excited states but influences the kinetics. Various consequences of binding on the form and photophysical parameters of the sensitizers are discussed and general features of the mutual interaction are outlined.
Hledání odpovědi na důležitou otázku:Jak zakotvení senzitizátoru v molekulárním assembly ovlivňuje jejich fotofyzikální vlastnosti.
Permanent Link: http://hdl.handle.net/11104/0008256
Number of the records: 1