Microarray-based identification of genes regulatrd by Ser/Thr protein kinase of Streptococcus pneumoniae

0100399 - MBU-M 20040088 RIV ES eng C - Conference Paper (international conference)
Přenosilová, Lenka - Nováková, Linda - Pallová, Petra - Branny, Pavel
Microarray-based identification of genes regulatrd by Ser/Thr protein kinase of Streptococcus pneumoniae.
[Identifikace genů, regulovaných Ser/Thr proteinkinasou Streptococcus pneumoniae, mikročipovou metodou.]
Euresco Conference Bacterial Neural Networks. San Feliu, 2004, s. 125.
[Bacterial Neural Networks, Euro Conference on Inter- and Intracellular Signalling, and Global Regulation in Bacteria /2004./. San Feliu de Guixols (ES), 08.05.2004-14.05.2004]
Institutional research plan: CEZ:AV0Z5020903
Keywords : stkp-del * dna
Subject RIV: EE - Microbiology, Virology

To identify the genes whose expression is controlled by protein kinase StkP we examined the transcription profile of DstkP mutant by DNA microarray technology. The transcript analysis revealed the StkP-dependent expression of many potential target loci. Out of 2,300 genes evaluated, 49 were found to be specifically and strongly upregulated in the DstkP strain, whereas 48 were downregulated.

K identifikaci genů, jejichž exprese je kontrolována funkcí proteinkinasy StkP byla použita metoda DNA čipů. Analýza transkripčních profilů prokázala, že z celkového počtu 2300 genů jich 49 bylo specificky indukováno a 48 reprimováno v mutantu stkP.
Permanent Link: http://hdl.handle.net/11104/0007901