A paradoxical hypothesis: Might a controlled immune supression help to rescue the immune response in a pro-inflammatory tumor microenvironment?

0099282 - MBÚ 2008 RIV IT eng C - Conference Paper (international conference)
Vannucci, Luca
A paradoxical hypothesis: Might a controlled immune supression help to rescue the immune response in a pro-inflammatory tumor microenvironment?
[Paradoxní hypoteza: Může kontrolovaná imunosuprese pomoci vyvolat imunitní odpověď v nádorovém prostředí?]
nternational Conference of the International Society of Cancer Microenvironment /4./. Florencie: AACR, 2007, s. 47-47.
[nternational Conference of the International Society of Cancer Microenvironment /4./. Florencie (IT), 06.03.2007-10.03.2007]
R&D Projects: GA AV ČR(CZ) IAA500200510
Institutional research plan: CEZ:AV0Z50200510
Keywords : immunity * cancer
Subject RIV: EC - Immunology

We propose the hypothesis that we need temporarely block the immunity to restart an effective anticancer response. The hypothesis is based on the new knowledge about proinflammatory cancer microenvironment and tumor immune escape. Carcer-bearing animals that received mild immunosuppressive treatment for a short time had reduction of cancer growth and lymphocytes were able to vigourosly produce IFN-gamma

Navrhujeme hypotézu pro dočasnou blokádu imunity za účelem znovu účinně indukovat protinádorovou imunitu. Hypotéza je založena na nových poznatcích o prozánětovém nádorovém mikroprostředí a úniku nádoru z imunitního dozoru. Experimentální zvířata s nádorem, která byla léčena mírnými imunosupresivy po krátkou dobu zpomalila nádorový růst a znatelně s zvýšila produkce IFN-gamma v lymfocytech
Permanent Link: http://hdl.handle.net/11104/0157945