Structural studies of humanin and its derivatives in the investigation of their neuroprotective role against Alzheimer's disease

0097794 - ÚOCHB 2008 RIV CZ eng C - Conference Paper (international conference)
Benaki, D. - Zikos, C. - Evangelou, A. - Vlassi, M. - Slaninová, Jiřina - Livaniou, E. - Mikros, E. - Pelecanou, M.
Structural studies of humanin and its derivatives in the investigation of their neuroprotective role against Alzheimer's disease.
[Strukturální studie humaninu a jeho analogů - neuroprotektivní role a Alzheimerova nemoc.]
Biologically Active Peptides. Praha: Ústav organické chemie a biochemie AV ČR, 2007 - (Slaninová, J.), s. 5-10. Collection Symposium Series, 9. ISBN 978-80-86241-28-9.
[Biologically Active Peptides /10./. Praha (CZ), 11.04.2007-13.04.2007]
R&D Projects: GA MŠMT ME 872
Institutional research plan: CEZ:AV0Z40550506
Keywords : humanin * neuroprotective activity * mode of action
Subject RIV: CE - Biochemistry

NMR and CD studies on humanin peptides in aqueous solution and in the presence of trifluoroethyl alcohol (TFE) are reported. The findings showed high flexibility in aqueous environment and the ability to adopt a partial helical conformation in the more lipophilic medium of 30% TFE.

Popsána NMR a CD studia peptidů typu humaninu ve vodném prostředí a v přítomnosti trifluoroetylalkoholu (TFE). Výsledky ukázaly vysokou flexibilitu ve vodném prostředí a schopnost zaujmout částečně helikální konformaci v lipofilnějším prostředí 30% TFE.
Permanent Link: http://hdl.handle.net/11104/0156861