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Local changes of higher-order chromatin structure during DSB-repair
- 1.0096720 - BFÚ 2008 IE eng A - Abstract
Falk, Martin - Lukášová, Emilie - Gabrielová, Barbora - Ondřej, Vladan - Kozubek, Stanislav
Local changes of higher-order chromatin structure during DSB-repair.
[Lokální změny struktury chromatinu vyššího řádu během reparace DSB.]
Abstract. Dublin, 2007. s. 1.
[RADAM Conference 2007, Radiation Damage in Biomolecules Conference. 19.06.2007-22.06.2007, Dublin]
R&D Projects: GA MŠMT(CZ) 1P05OC084; GA ČR(CZ) GP204/06/P349
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : DSB repair * chromatin structure & dynamics * histone modifications
Subject RIV: BO - Biophysics
DSBs located in dense chromatin protruded into the low-density chromatin domains early after cell irradiation, in order to be repaired. This process was associated with local histone acetylation and chromatin decondensation at sites of DSB lesions.
V hustém chromatinu lokalizované DSBs se krátce po ozáření přesouvaly do oblastí s nízkou hustotou chromatinu za účelem reparace. Tento proces byl doprovázen acetylací histonů a dekondenzací chromatinu v místech DSB lezí.
Permanent Link: http://hdl.handle.net/11104/0156016
Number of the records: 1