Composite hyaluronate-type I collagen-fibrin scaffold in the therapy of osteochondral defects in miniature pigs

0095024 - ÚEM 2008 RIV CZ eng J - Journal Article
Filová, Eva - Rampichová, Michala - Handl, M. - Lytvynets, Andrej - Halouzka, R. - Usvald, Dušan - Hlučilová, Jana - Procházka, Radek - Dezortová, M. - Rolencová, E. - Košťáková, E. - Trč, T. - Šťastný, E. - Koláčná, Lucie - Hájek, M. - Motlík, Jan - Amler, Evžen
Composite hyaluronate-type I collagen-fibrin scaffold in the therapy of osteochondral defects in miniature pigs.
[Složená matrice z hyaluronanu, kolagenu typu I a fibrinu v terapii1.]
Physiological Research. Roč. 56, Suppl. 1 (2007), S5-S16. ISSN 0862-8408. E-ISSN 1802-9973
R&D Projects: GA AV ČR(CZ) 1ET400110403; GA AV ČR IAA500390702; GA MŠMT 2B06130; GA ČR(CZ) GA304/05/0327
Grant - others:-(CZ) 1M6798582302
Institutional research plan: CEZ:AV0Z50390512; CEZ:AV0Z50110509; CEZ:AV0Z50450515
Source of funding: V - Other public resources
Keywords : Osteochondral defect * Fibrin * Autologous chondrocytes
Subject RIV: BO - Biophysics
Impact factor: 1.505, year: 2007

Regeneration of osteochondral defects using novel composite hyaluronate-type I collagen-fibrin scaffold seeded with autologous chondrocytes was studied. Six months after the implantation, the hyaline cartilage and fibrocartilage were formed in the defects which proved the scaffold application for regeneration of cartilage defects.

Byla hodnocena regenerace osteochondrálních defektů pomocí nové kompozitní matrice složené z hyaluronanu sodného, kolagenu typu I a fibrinu a osazené autologními chondrocyty. Šest měsíců po implantaci se v defektech vytvořila hyalinní a fibrózní chrupavka, což dokazuje potenciální využití scaffoldu v terapii chrupavkových defektů.
Permanent Link: http://hdl.handle.net/11104/0154703