Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect

0093924 - ÚEM 2008 RIV GB eng J - Journal Article
Pechlivanis, S. - Pardini, Barbara - Bermejo, J.L. - Wagner, K. - Naccarati, Alessio - Vodičková, Ludmila - Novotný, J. - Hemminki, K. - Vodička, Pavel - Försti, A.
Insulin pathway related genes and risk of colorectal cancer: INSR promoter polymorphism shows a protective effect.
[Geny insulinove drahy a riziko kolorektalniho karcinomu: polymorfismus v.]
Endocrine-Related Cancer. Roč. 14, - (2007), s. 733-740. ISSN 1351-0088. E-ISSN 1479-6821
R&D Projects: GA ČR GA310/05/2626; GA ČR GA310/07/1430; GA MZd NR8563
Grant - others:EU(SE) 503465
Institutional research plan: CEZ:AV0Z50390512
Source of funding: R - Framework programmes of European Commission
Keywords : Colorectal cancer
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 5.193, year: 2007

Authors studied the association of five single nucleotide polymorphisms (SNPs) with the risk of colorectal cancer (CRC) in a hospital-based case-control design with 712 cases and 748 controls from the Czech Republic. The INSR A603G promoter SNP was associated with the risk of CRC (ORs for the variant allele 0.71, CI95% 0.54-0.93). The variant allele of the IRS1 polymorphism further decreased the risk among INSR-603G allele carriers (ORs 0.28, CI95% 0.11-0.70). SNPs in the INS, IGFBP1, and IRS2 genes did not affect the risk of CRC.

Autoři předpokládají, že funkční polymorfizmy v genech inzulínové dráhy INS, INSR, IGFBPI, IRS1 a IRS2 mohou být spojovány s rakovinou kolorektálního karcinomu (CRC). Sledovala se asociace mezi 5 polymorfismy a rizikem vzniku CRC u 712 pacientů a 748 kontrol v České Republice. Zjistilo se, že INSR A-603G promotor SNP byl asociován s rizikem vzniku CRC, nositelé G alely měli snížené riziko vzniku CRC (OR= 0.71, 95% confidence interval (CI) 0.54-0.93). SNP v INS, IGFBPI a IRS2 genech neovlivňovaly riziko vzniku CRC.
Permanent Link: http://hdl.handle.net/11104/0153837