Creatine kinase binds more firmly to the M-band of rabbit skeletal muscle myofibrils in the presence of its substrates

0089454 - FGÚ 2008 RIV US eng J - Journal Article
Žurmanová, Jitka - Difato, F. - Maláčová, Daniela - Mejsnar, J. - Štefl, B. - Zahradník, I.
Creatine kinase binds more firmly to the M-band of rabbit skeletal muscle myofibrils in the presence of its substrates.
[Kreatin-kináza tvoří pevnější vazbu s M-skupinou v myofibrilách kosterního svalu králíka v přítomnosti substrátů.]
Molecular and Cellular Biochemistry. Roč. 305, 1-2 (2007), s. 55-61. ISSN 0300-8177. E-ISSN 1573-4919
R&D Projects: GA ČR(CZ) GA304/05/0327
Grant - others:MYORES(XE) LSHG-CT-2004-511978
Institutional research plan: CEZ:AV0Z50110509
Source of funding: R - Framework programmes of European Commission
Keywords : muscle * creatine kinase * myofibrillar-sarcoplasmic exchange
Subject RIV: ED - Physiology
Impact factor: 1.707, year: 2007

We have studied the interaction of CK with myofibrils and the role of different conformational states of CK molecule induced by ATP, phosphocreatine, ADP and ATP-creatine pair. The results show that the substrates slowed down the exchange rate. This indicate that the strength of the bond between CK and the M-band of myofibrils increased

Studovali jsme interakci kreatin-kinázy s myofibrilami navozenou ATP, fosfokreatinem, ADP a ATP-kreatinem. Výsledky ukázaly, že vazba mezi molekulou kreatin-kinázy a myofibrilami vzrostla
Permanent Link: http://hdl.handle.net/11104/0150662