A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse–axial tubular system

0087223 - ÚT 2009 RIV GB eng J - Journal Article
Pásek, Michal - Šimurda, J. - Orchard, C. - Christé, G.
A model of the guinea-pig ventricular cardiac myocyte incorporating a transverse–axial tubular system.
[Model srdeční komorové buňky morčete zahrnující transverzálně-axiální tubulární systém.]
Progress in Biophysics & Molecular Biology. Roč. 96, 1-3 (2008), s. 258-280. ISSN 0079-6107. E-ISSN 1873-1732
Institutional research plan: CEZ:AV0Z20760514
Keywords : guinea pig * cardiac cell * transverse-axial tubular system * quantitative model
Subject RIV: BO - Biophysics
Impact factor: 6.388, year: 2008

A model of the guinea-pig cardiac ventricular myocyte has been developed that includes a representation of the transverse–axial tubular system (TATS), including heterogeneous distribution of ion flux pathways between the surface and tubular membranes. The model reproduces frequency-dependent changes of action potential shape and intracellular ion concentrations and can replicate experimental data showing ion diffusion between the tubular lumen and external solution in guinea-pig myocytes. The model is stable at rest and during activity and returns to rested state after perturbation. Theoretical analysis and model simulations show that, due to tight electrical coupling, tubular and surface membranes behave as a homogeneous whole during voltage and current clamp (maximum difference 0.9mV at peak tubular INa of 38 nA).

Práce prezentuje matematický model elektrické aktivity srdeční komorové buňky morčete zahrnující funkci transverzálně axiálního tubulárního systému (TATS). Představené výsledky simulací odhalují fyziologický význam TATS u srdečních buněk.
Permanent Link: http://hdl.handle.net/11104/0149124