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Effects of oncogenic fusion proteins on chromatin PML-RAR - A model to cure leukemia

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    0080973 - BFÚ 2007 US eng A - Abstract
    Pellicci, P. G. - Falk, Martin - Lukášová, Emilie - Kozubek, Stanislav
    Effects of oncogenic fusion proteins on chromatin PML-RAR - A model to cure leukemia.
    [Vliv onkogenních fúzních proteinů na chromatin - PML-RAR jako model pro léčbu leukémií.]
    Abstract. La Jolla, 2007. s. 28-28.
    [Symposium on Biological Complexity: Diseases of Transcription. 11.01.2007-14.01.2007, La Jolla]
    R&D Projects: GA ČR(CZ) GP204/06/P349; GA MŠMT(CZ) 1P05OC084; GA MŠMT(CZ) LC535
    Institutional research plan: CEZ:AV0Z50040507
    Keywords : PML/RARa oncogene * acute promyelocytic leukemia * gene down-regulation
    Subject RIV: BO - Biophysics

    In this work we describe a totaly new mechanism of gene down-regulation in acute promyelocytic leukemia mediated by the PML/RARa fusion protein.

    V této práci popisujeme zcela nový mechanismus patologického utlumení genové exprese u akutní promyelocytární leukémie fúzním proteinem PML/RARa.
    Permanent Link: http://hdl.handle.net/11104/0144985

     
     
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