The supposedly attenuated Hy-HK variant of highly virulent Hypr strain of Tick-borne encephalitis virus is obviously a strain of Langat virus

0048620 - BC 2007 RIV SK eng J - Journal Article
Růžek, Daniel - Štěrba, Ján - Kopecký, Jan - Grubhoffer, Libor
The supposedly attenuated Hy-HK variant of highly virulent Hypr strain of Tick-borne encephalitis virus is obviously a strain of Langat virus.
[Virus Hy-HK, považovaný za atenuovanou variantu vysoce virulentního kmene Hypr viru klíšťové encefalitidy, je ve skutečnosti kmenem viru Langat.]
Acta virologica. Roč. 50, č. 4 (2006), s. 277-278. ISSN 0001-723X. E-ISSN 1336-2305
R&D Projects: GA ČR(CZ) GA524/06/1479
Grant - others:Grant Agency of the University of South Bohemia(CZ) 35/2005/P-BF
Institutional research plan: CEZ:AV0Z60220518
Keywords : TBE virus * Langat virus * Hy-HK attenuated variant
Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine
Impact factor: 0.788, year: 2006

The study showed that some of the classical studies (Mayer et al., 1966-1970) focused on the pathogenesis of TBE brought mistaken results because they were based on the experiments with Langat virus instead of TBE virus. Consequently, now it is time to reexamine the general features of TBE pathogensis using modern molecular biology approach. To emphasize the assignment of the Hy-HK variant to Langat virus we propose to use in a new name, e.g. Langat Hy-HK.

Studium viru Hy-HK odhalilo, že klasické práce Mayera a kol. z let 1966 až 1970 věnované patogenezi KE byly chybné, neboť byly založeny na experimentech s virem Langat namísto viru KE. Následně je třeba přezkoumat patogenezi viru KE s využitím moderních metod molekulární biologie. Pro udržení významové souvislosti navrhujeme nové označení viru, např. virus Langat Hy-HK.
Permanent Link: http://hdl.handle.net/11104/0139216