Quantitative structure–activity relationships for toxicity and genotoxicity of halogenated aliphatic compounds: Wing spot test of Drosophila melanogaster

0048335 - ÚBO 2007 RIV GB eng J - Journal Article
Chroust, K. - Pavlová, M. - Prokop, Z. - Mendel, Jan - Božková, K. - Kubát, Z. - Zajíčková, V. - Damborský, J.
Quantitative structure–activity relationships for toxicity and genotoxicity of halogenated aliphatic compounds: Wing spot test of Drosophila melanogaster.
[QSAR pro toxicitu a genotoxicitu halogenovaných alifatických sloučenin: "Wing Spot Test" na Drosophila melanogaster.]
Chemosphere. Roč. 67, č. 1 (2007), s. 152-159. ISSN 0045-6535. E-ISSN 1879-1298
Institutional research plan: CEZ:AV0Z60930519
Keywords : toxicity * wing spot test * QSAR
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.739, year: 2007

Halogenated aliphatic compounds were evaluated for toxic and genotoxic effects in the somatic mutation and recombination test employing Drosophila melanogaster. The tested chemicals included chlorinated, brominated and iodinated; mono-, di- and tri-substituted; saturated and unsaturated alkanes. The set of chemicals for the toxicological testing was selected by the use of statistical experiment design. Group of unsaturated aliphatic hydrocarbons were generally more toxic than saturated analogues. The genotoxic effect was observed with 14 compounds in the wing spot test, while 3 substances did not show any genotoxicity by using wing spot test at 50% lethal concentration. The highest number of wing spots was observed in genotoxicity assay with 1-bromo-2-chloroethane, 1,2-dichloroethane, 1,2-dibromoethane and 1-iodopropane. Nucleophilic superdelocalizability calculated by quantum mechanics appears to be a good parameter for prediction of both toxicity and genotoxicity effects.

U halogenovaných alifatických sloučenin byly hodnoceny toxické a genotoxické efekty na somatické mutace a rekombinace u Drosophil melanogaster. Test chemikálií zahrnoval chlorované, bromované a iodované, mono-, di- a tri- substituenty.
Permanent Link: http://hdl.handle.net/11104/0138993