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Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer
- 1.0044735 - ÚOCHB 2007 RIV GB eng J - Journal Article
Mesters, J. R. - Bařinka, Cyril - Li, W. - Tsukamoto, T. - Majer, P. - Slusher, B. - Konvalinka, Jan - Hilgenfeld, R.
Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.
[Struktura GCP II, léčebného cíle při neuronálním poškození a nádorech prostaty.]
EMBO Journal. Roč. 25, č. 6 (2006), s. 1375-1384. ISSN 0261-4189. E-ISSN 1460-2075
R&D Projects: GA ČR(CZ) GA301/03/0784; GA MŠMT 1M0508
Institutional research plan: CEZ:AV0Z40550506
Keywords : NAALADase * neurodegenerative disease * peptidase * prostate cancer
Subject RIV: CE - Biochemistry
Impact factor: 10.086, year: 2006
The three-dimensional structures presented here reveal an induced-fit substrate-binding mode of this key enzyme and provide essential information for the design of GCPII inhibitors useful in the treatment of neuronal diseases and prostate cancer.
Byla vyřešena 3-D struktura enzymu GCPII rentgenovou difrakcí. Struktura vysvětluje, jak se na enzymu váže substrát a inhibitory.
Permanent Link: http://hdl.handle.net/11104/0137447
Number of the records: 1