Fibroblast growth factor signaling in embryonic and cancer stem cells

0043402 - ÚEM 2007 RIV GB eng J - Journal Article
Dvořák, Petr - Dvořáková, D. - Hampl, Aleš
Fibroblast growth factor signaling in embryonic and cancer stem cells.
[Signální dráhy fibroblastového růstového faktoru v embryonálních kmenových nádorových buňkách.]
FEBS Letters. Roč. 580, - (2006), s. 2869-2874. ISSN 0014-5793. E-ISSN 1873-3468
R&D Projects: GA MŠMT 1M0538; GA ČR GA301/03/1122
Institutional research plan: CEZ:AV0Z50390512
Keywords : Fibroblast growth factor 2 * Embryonic stem cell * Hematopoietic progenitor cell
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 3.372, year: 2006

The fibroblast growth factor 2 (FGF-2) pathway is one of the most significant regulators of human embryonic stem cell (hESC) self-renewal and cancer cell tumorigenesis. In this paper we summarize recent data on the effects of FGF-2 and its receptors on hESCs and leukemic stem/progenitor cells. Also we discuss the similarities of these findings with stem cell renewal and differentiation phenotypes.

The fibroblast growth factor 2 (FGF-2) pathway is one of the most significant regulators of human embryonic stem cell (hESC) self-renewal and cancer cell tumorigenesis. In this paper we summarize recent data on the effects of FGF-2 and its receptors on hESCs and leukemic stem/progenitor cells. Also we discuss the similarities of these findings with stem cell renewal and differentiation phenotypes.
Permanent Link: http://hdl.handle.net/11104/0136403