Antimutagenic constituents from the thorns of Gleditsia sinensis

0031547 - ÚOCHB 2006 RIV JP eng J - Journal Article
Lim, J. Ch. - Park, J. H. - Buděšínský, Miloš - Kasal, Alexander - Han, Y. H. - Koo, B. S. - Lee, S. I. - Lee, D. U.
Antimutagenic constituents from the thorns of Gleditsia sinensis.
[Antimutagenní deriváty z trnů Gleditsia sinensis.]
Chemical & Pharmaceutical Bulletin. Roč. 53, č. 5 (2005), s. 561-564. ISSN 0009-2363
Grant - others:KRFG(KR) KRF-2001-041-F00290
Institutional research plan: CEZ:AV0Z4055905
Keywords : Gleditsia sinensis * antimutagenic activity * stigmasterol
Subject RIV: CC - Organic Chemistry
Impact factor: 1.246, year: 2005

Thorns of Gleditsia sinensis were extracted and following compounds were identified: D:C-friedours-7-en-3-one, stigmast-4-en-3,6-dione, stigmasta-3,6-dione, stigmasterol a beta-sitosterol. Their biological activity was studied, stigmasterol proved to be the most active antimutagen of the lot. NMR Data of some steroid derivatives were revised.

Z trnů Gleditsia sinensis byl isolován D:C-friedours-7-en-3-on, stigmast-4-en-3,6-dion, stigmasta-3,6-dion, stigmasterol a beta-sitosterol. Jejich biologická aktivita byla studována, stigmasterol se ukázal jako nejaktivnější antimutagen. Údaje o NMR datech některých isolovaných látek byly revidovány.
Permanent Link: http://hdl.handle.net/11104/0132247