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Different roles of peptidic spacers in proteolytically and hydrolytically cleavable HPMA-based polymeric prodrugs
- 1.0027463 - MBÚ 2006 RIV SIGLE US eng C - Conference Paper (international conference)
Hovorka, Ondřej - Císlerová, Lucie - Strohalm, Jiří - Šubr, Vladimír - Ulbrich, Karel - Říhová, Blanka
Different roles of peptidic spacers in proteolytically and hydrolytically cleavable HPMA-based polymeric prodrugs.
[Rozdílné role peptidických spojek v proteolyticky a hydrolyticky štěpitelných polymerních proléčivech na bázi HPMA.]
International Symposium on Recent Advances in Drug Delivery Systems /12./. Salt Lake City, 2005, s. 85-85.
[International Nanomedicine and Drug Delivery Symposium /3./. Baltimore (US), 26.09.2005-27.09.2005]
R&D Projects: GA ČR GA305/05/2268; GA ČR GA204/05/2255
Institutional research plan: CEZ:AV0Z50200510
Keywords : hpma * doxorubicin
Subject RIV: EE - Microbiology, Virology
We have tested two types of HPMA-based polymeric prodrugs containing doxorubicin, one with proteolitically and the other with hydrolitically cleavable spacers. We have found significant difference in the uptake, internalization and mediation of cell death of the tested conjugates
Testovali jsme dva typy polymerních proléčiv obsahujících doxorubicin založených na HPMA, jedny s proteolyticky a druhé s hydrolyticky štěpitelnými spojkami. Zjistili jsme výrazné rozdíly ve vstupu konjugátů do buňky, v jejich internalizaci a ve způsobu zprostředkování buněčné smrti
Permanent Link: http://hdl.handle.net/11104/0117564
Number of the records: 1