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Ontogenesis of photoperiodic entrainment of the molecular core clockwork in the rat suprachiasmatic nucleus

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    0026831 - FGÚ 2006 RIV NL eng J - Journal Article
    Kováčiková, Zuzana - Sládek, Martin - Laurinová, Kristýna - Bendová, Zdeňka - Illnerová, Helena - Sumová, Alena
    Ontogenesis of photoperiodic entrainment of the molecular core clockwork in the rat suprachiasmatic nucleus.
    [Ontogeneze fotoperiodické synchronizace molekulárního mechanismu hodin v suprachiasmatických jádrech potkana.]
    Brain Research. Roč. 1064, č. 1-2 (2005), s. 83-89. ISSN 0006-8993. E-ISSN 1872-6240
    R&D Projects: GA MŠMT(CZ) LC554; GA ČR(CZ) GA309/02/1241; GA ČR(CZ) GA309/05/0350; GA ČR(CZ) GP309/02/D093
    Institutional research plan: CEZ:AV0Z50110509
    Keywords : suprachiasmatic nucleus * ontogenesis * photoperiod
    Subject RIV: ED - Physiology
    Impact factor: 2.296, year: 2005

    While the photoperiod does not affect rhythmical expression of clock genes Per1, Per2, Cry1 and Bmal1 in 3-day-old pups, in 10-day-old pups the profiles in expression of Per1 and Per2 are already entrained. In 20-day-old pups, the profile in Cry1 but not in Bmal1 is entrained. The developmental interval when the photoperiod begins to entrain the core clock mechanism completely might thus occur around the time of weaning

    Zatímco u 3-denních mláďat fotoperioda ještě neovlivňuje rytmickou expresi hodinových genů Per1, Per2, Cry1 a Bmal1, u 10-denních mláďat je již seřízen profil v expresi genů Per1 a Per2. U 20-denních mláďat je navíc fotoperiodou synchronizován i rytmus v expresi Cry1, avšak ne v expresi Bmal1. Vývojový interval, kdy fotoperioda začíná synchronizovat molekulární mechanismus cirkadiánních hodin tak nastává okolo doby odstavu
    Permanent Link: http://hdl.handle.net/11104/0117004

     
     
Number of the records: 1  

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