Nuclear distribution of actin and myosin I depends on transcriptional activity

0025654 - ÚEM 2006 RIV DE eng J - Journal Article
Kyselá, Katarína - Philimonenko, Anatolij - Philimonenko, Vlada - Janáček, Jiří - Kahle, Michal - Hozák, Pavel
Nuclear distribution of actin and myosin I depends on transcriptional activity.
[Jaderná distribuce aktinu a myosinu I zavisející na transkripční aktivitě buňky.]
Histochemistry and Cell Biology. Roč. 124, č. 5 (2005), s. 347-358. ISSN 0948-6143. E-ISSN 1432-119X
R&D Projects: GA ČR GA204/04/0108; GA ČR GP304/03/P118; GA AV ČR IAA5039202
Institutional research plan: CEZ:AV0Z5039906; CEZ:AV0Z50110509
Keywords : cell nucleus * human lymphocytes
Subject RIV: EA - Cell Biology
Impact factor: 2.239, year: 2005

As previous studies suggested, nuclear myosin I (NMI) and actin have important roles in DNA transcription. In this study, we characterized the dynamics of these two proteins during transcriptional activation in phytohemagglutinin (PHA) stimulated human lymphocytes. Results demonstrate that actin and NMI are compartmentalized in the nuclei where they can dynamically translocate depending on transcriptional activity of the cells.

Charakterizována byla dynamika jaderného myosinu a aktinu během aktivace lidských lymfocytů. Výsledky ukázaly, že oba proteiny jsou v jádře kompartmentalizovány a dynamicky se přesouvají v závislosti na transkripční aktivitě buňky.
Permanent Link: http://hdl.handle.net/11104/0116025