2',5'-linked oligo-3'-deoxynucleotide chimeras with chiral alpha-hydroxyphosphonate internucleotide linkage: Improvement of hybridisation selectivity toward RNA?

0022984 - ÚOCHB 2006 RIV CZ eng C - Conference Paper (international conference)
Králíková, Šárka - Buděšínský, Miloš - Liboska, Radek - Páv, Ondřej - Rosenberg, Ivan
2',5'-linked oligo-3'-deoxynucleotide chimeras with chiral alpha-hydroxyphosphonate internucleotide linkage: Improvement of hybridisation selectivity toward RNA?
[Oligo-3'-deoxynukleotidy s chirální alfa-hydroxyfosfonátovou 2',5' internukleotidovou vazbou: zlepšení hybridizační selektivity vůči RNA?]
Chemistry of Nucleic Acid Components. Praha: ÚOCHB AV ČR, 2005 - (Hocek, M.), s. 421-422. Collection Symposium Series, 7. ISBN 80-86241-25-4.
[Chemistry of Nucleic Acid Components /13./. Špindlerův Mlýn (CZ), 03.09.2005-09.09.2005]
R&D Projects: GA AV ČR(CZ) IAA4055101; GA ČR(CZ) GP203/04/P273
Institutional research plan: CEZ:AV0Z40550506
Keywords : oligonucleotides * hydroxyphosphonates * 2'-5' linkage
Subject RIV: CC - Organic Chemistry

Synthesis and hybridization selectivity of 9-mers 5’-d(GTG ATA TGC)-3’ (T means modified units) containing both hydroxyphosphonate and phosphodiester 2’-5’ internucleotide linkages toward complementary DNA and RNA counterpart were investigated.

Byly syntetizovány 9-mery 5’-d(GTG ATA TGC)-3’ (T je modifikovaná jednotka), které obsahovaly jak hydroxyfosfonátové tak fosfodiesterové 2’-5’ internukleotidové vazby a byla zkoumána jejich hybridizační selektivita vůči DNA and RNA.
Permanent Link: http://hdl.handle.net/11104/0111674