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Monomers for novel phosphonate oligonucleotides potential RNase L inhibitors

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    0022981 - ÚOCHB 2006 RIV CZ eng C - Conference Paper (international conference)
    Liboska, Radek - Páv, Ondřej - Rosenberg, Ivan
    Monomers for novel phosphonate oligonucleotides potential RNase L inhibitors.
    [Monomery pro nové fosfonátové oligonukleotidy, potenciální inhibitory RNasy L.]
    Chemistry of Nucleic Acid Components. Praha: ÚOCHB AV ČR, 2005 - (Hocek, M.), s. 437-438. Collection Symposium Series, 7. ISBN 80-86241-25-4.
    [Chemistry of Nucleic Acid Components /13./. Špindlerův Mlýn (CZ), 03.09.2005-09.09.2005]
    R&D Projects: GA AV ČR(CZ) IAA4055101
    Institutional research plan: CEZ:AV0Z40550506
    Keywords : phosphonoalkylidene * phosphonates * oligoadenylates
    Subject RIV: CC - Organic Chemistry

    Synthetic route for the preparation of 2',3'-O-phosphonoalkylidene , and 3',5'-O-phosphonoalkylidene ribonucleotide monomers for automated oligonucleotide synthesis (a phosphotriester condensation approach) has been developed.

    Práce popisuje syntetický postup přípravy 2',3'-O-fosfonoalkylidenových a 3',5'-O-fosfonoalkylidenových ribonukleotidových monomerů pro automatizovanou syntézu oligonukleotidů fosfotriesterovou metodou.
    Permanent Link: http://hdl.handle.net/11104/0111671

     
     
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