PYRAZOLO [4, 3-D]PYRIMIDINES, PROCESSES FOR THEIR PREPARATION AND METHODS OF USE

0000304 - ÚEB 2005 RIV DE eng P - Patent Document
Moravcová, Daniela - Havlíček, Libor - Kryštof, Vladimír - Lenobel, René - Binarová, Pavla - Mlejnek, P. - Vojtěšek, B. - Uldrijan, S. - Schmülling, T. - Strnad, Miroslav
PYRAZOLO [4, 3-D]PYRIMIDINES, PROCESSES FOR THEIR PREPARATION AND METHODS OF USE.
[PYRAZOLO [4, 3-D]PYRIMIDINEY, ZPŮSOBY JEJICH PŘÍPRAVY A METODY POUŽITÍ.]
München: European Patent Office, 2004. Owner: Ústav experimentální botaniky AV ČR. Date of the patent registration: 05.04.2004. Date of the patent acceptance: 12.12.2004. 52 s. Patent Number: WO2004098608
Institutional research plan: CEZ:AV0Z5038910
Keywords : pyrimidine * anticancer drug
Subject RIV: CE - Biochemistry
http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2004098608&F=0

The invention relates to 3-, 7-disubstituted pyrazolo[4,3-d]pyrimidines represented by the general formula I (I), and pharmaceutically acceptable salts thereof, wherein R3 is selected from the group consisting of alkyl, cycloalkyl, , cycloalkyl alkyl, cycloheteroalkyl alkyl, cycloheteroalkyl, aryl, heterocycle, heteroaryl, arylalkyl, heteroarylalkyl, and heteroalkyl, wherein each of the groups may optionally be substituted, R7 is selected from the group consisting of halogen, hydroxyl, hydroxylamino, amino, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, unsubstituted or substituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heteroarylakyl, substituted or unsubstituted cycloalkyl alkyl, substituted or unsubstituted cycloheteroalkyl alkyl; R7'-X- wherein X is an -NH-, -N(alkyl)-, -0- or -S- moiety and R7' is selected from the group consisting of H, alkyl, cycloalkyl, aryl, alkylcycloalkyl, arylalkyl, heterocycle, heterocyclealkyl, substituted alkyl, substituted cycloalkyl, substituted aryl, substituted arylalkyl, substituted heterocycle, substituted heteroaryl, substituted heteroarylalkyl, substituted heteroalkyl, substituted cycloalkyl alkyl and substituted cycloheteroalkyl alkyl, wherein the groups are preferably substituted by more than one halogen, hydroxyl, amino, mercapto, carboxyl, cyano, nitro, amido, sulfo, sulfamido, carbamino, alkyl, alkoxy, and substituted alkyl group.

PYRAZOLO [4, 3-D]PYRIMIDINEY, ZPŮSOBY JEJICH PŘÍPRAVY A METODY POUŽITÍ
Permanent Link: http://hdl.handle.net/11104/0017579