Výsledky vyhledávání
- 1.0548469 - ÚOCHB 2022 CZ eng A - Abstrakt
Hadzima, Martin - Houštecká, Radka - Pallová, Lenka - Hánová, Iva - Fanfrlík, Jindřich - Brynda, Jiří - Lepšík, Martin - Mertlíková-Kaiserová, Helena - Horn, Martin - Mareš, Michael - Majer, Pavel
Design, Synthesis and Activity of Biomimetic Macrocyclic Inhibitors of Human Cathepsin D.
Liblice 2021. 55th Advances in Organic, Bioorganic and Pharmaceutical Chemistry. Praha: Czech Chemical Society, 2021. s. 112.
[Liblice 2021. Advances in Organic, Bioorganic and Pharmaceutical Chemistry /55./. 03.11.2021-06.11.2021, Špindlerův Mlýn]
Institucionální podpora: RVO:61388963
Klíčová slova: inhibitor * cathepsin * macrocycles * peptides * statine * synthesis
Obor OECD: Medicinal chemistry
Trvalý link: http://hdl.handle.net/11104/0324491 - 2.0521200 - ÚOCHB 2020 US eng A - Abstrakt
Hadzima, Martin - Houštecká, Radka - Pallová, Lenka - Fanfrlík, Jindřich - Brynda, Jiří - Lepšík, Martin - Horn, Martin - Mareš, Michael - Majer, Pavel
Design, Synthesis and Activity of Biomimetic Macrocyclic Inhibitors of Human Cathepsin D.
Boulder Peptide Symposium 2019. Boulder: Boulder Peptide Society, 2019.
[Boulder Peptide Symposium 2019. 23.09.2019-26.09.2019, Boulder]
Institucionální podpora: RVO:61388963
Klíčová slova: inhibitor * cathepsin * macrocycles * peptides * statine * synthesis
Obor OECD: Medicinal chemistry
Trvalý link: http://hdl.handle.net/11104/0305838 - 3.0521191 - ÚOCHB 2020 GR eng A - Abstrakt
Hadzima, Martin - Houštecká, Radka - Pallová, Lenka - Fanfrlík, Jindřich - Brynda, Jiří - Lepšík, Martin - Horn, Martin - Mareš, Michael - Majer, Pavel
Design, Synthesis and Activity of Biomimetic Macrocyclic Inhibitors of Human Cathepsin D.
EFMC-ASMC’19. 8th EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry. Athens: European Federation for Medicinal Chemistry, 2019. s. 187.
[EFMC-ASMC’19. EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry /8./. 01.09.2019-05.09.2019, Athens]
Institucionální podpora: RVO:61388963
Klíčová slova: inhibitor * cathepsin * macrocycles * peptides * statine * synthesis
Obor OECD: Medicinal chemistry
Trvalý link: http://hdl.handle.net/11104/0305833 - 4.0491273 - ÚOCHB 2019 CZ eng A - Abstrakt
Srb, Pavel - Svoboda, Michal - Benda, L. - Lepšík, Martin - Tarábek, Ján - Šícha, Václav - Grüner, Bohumír - Grantz Šašková, Klára - Brynda, Jiří - Řezáčová, Pavlína - Konvalinka, Jan - Veverka, Václav
Capturing dynamically interacting inhibitor by paramagnetic NMR spectroscopy.
Prague Protein Spring Meeting 2018: Proteins at Work. Praha: Ústav organické chemie a biochemie AV ČR, 2018 - (Votrubová, T.; Pergl Šustková, H.; Vondrášek, J.). s. 70. ISBN 978-80-86241-58-6.
[Prague Protein Spring Meeting 2018: Proteins at Work. 03.05.2018-06.05.2018, Praha]
Institucionální podpora: RVO:61388963 ; RVO:61388980
Klíčová slova: paramagnetic ligands * intermolecular interactions * HIV-1 protease
Obor OECD: Biochemistry and molecular biology
Trvalý link: http://hdl.handle.net/11104/0285577 - 5.0487071 - ÚOCHB 2018 CA eng A - Abstrakt
Jílková, Adéla - Rubešová, Petra - Řezáčová, Pavlína - Fanfrlík, Jindřich - Fajtová, Pavla - Brynda, Jiří - Lepšík, Martin - Horn, Martin - McKerrow, J. H. - Caffrey, C. R. - Mareš, Michael
Exploring druggable hot spots in Schistosoma mansoni cathepsin B1 for structure-based design of vinyl sulfone inhibitors.
IPS 2017. 10th General Meeting of the International Proteolysis Society. Banff: International Proteolysis Society, 2017. s. 152.
[IPS 2017. General Meeting of the International Proteolysis Society /10./. 28.10.2017-02.11.2017, Banff]
Grant CEP: GA MŠMT(CZ) LH15040; GA MŠMT LO1302
Institucionální podpora: RVO:61388963
Klíčová slova: Schistosoma mansoni * SmCB1
Kód oboru RIV: CE - Biochemie
Trvalý link: http://hdl.handle.net/11104/0281755 - 6.0487070 - ÚOCHB 2018 CA eng A - Abstrakt
Hobizalová, Radka - Palová, Lenka - Fanfrlík, Jindřich - Brynda, Jiří - Monincová, Lenka - Lepšík, Martin - Horn, Martin - Majer, Pavel - Mareš, Michael
Novel macrocyclic inhibitors of human cathepsin D.
IPS 2017. 10th General Meeting of the International Proteolysis Society. Banff: International Proteolysis Society, 2017. s. 150.
[IPS 2017. General Meeting of the International Proteolysis Society /10./. 28.10.2017-02.11.2017, Banff]
Grant CEP: GA ČR GA15-18929S; GA MŠMT LO1302
Institucionální podpora: RVO:61388963
Klíčová slova: human cathepsin D * inhibitors
Kód oboru RIV: CE - Biochemie
Trvalý link: http://hdl.handle.net/11104/0281750 - 7.0485485 - ÚOCHB 2018 DE eng A - Abstrakt
Eyrilmez, Saltuk M. - Lepšík, Martin - Hobza, Pavel - Fanfrlík, Jindřich - Hnyk, Drahomír
Interactions of binary twinned-icosahedral [B21H18]- with cyclodextrins.
WATOC 2017. 11th Triennial Congress of the World Association of Theoretical and Computational Chemists. Munich: World Association of Theoretical and Computational Chemists, 2017. PO3.277.
[WATOC 2014. Triennial Congress of the World Association of Theoretical and Computational Chemists /10./. 27.08.2017-01.09.2017, Munich]
Institucionální podpora: RVO:61388963 ; RVO:61388980
Klíčová slova: cyclodextrin * boron hydride anions
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie; CA - Anorganická chemie (UACH-T)
Trvalý link: http://hdl.handle.net/11104/0280736 - 8.0465007 - ÚOCHB 2017 NL eng A - Abstrakt
Frydrych, Jan - Dračínský, Martin - Gnanasekaran, Ramachandran - Lepšík, Martin - Šmídková, Markéta - Tloušťová, Eva - Mertlíková-Kaiserová, Helena - Janeba, Zlatko
Novel adenine acyclic nucleoside phosphonates and their derivatives as potent inhibitors of bacterial adenylate cyclases.
ECHC 2016. 27th European Colloquium on Heterocyclic Chemistry. Amsterdam: -, 2016.
[ECHC 2016. European Colloquium on Heterocyclic Chemistry /27./. 03.07.2016-06.07.2016, Amsterdam]
Grant CEP: GA MV VG20102015046; GA ČR(CZ) GBP208/12/G016; GA MŠMT LO1302
Institucionální podpora: RVO:61388963
Klíčová slova: acyclic nuceloside phosphonates * bacterial adenylate cyclases
Kód oboru RIV: CC - Organická chemie
Trvalý link: http://hdl.handle.net/11104/0263730 - 9.0459939 - ÚOCHB 2017 CZ eng A - Abstrakt
Lepšík, Martin - Ajani, Haresh - Haldar, Susanta - Fanfrlík, Jindřich - Hobza, Pavel
Explicit-solvent effects in protein-ligand binding: Molecular dynamics complements quantum mechanical scoring.
Prague Protein Spring Meeting 2016: Proteins and their Design. Praha: Ústav organické chemie a biochemie AV ČR, 2016. s. 69. ISBN 978-80-86241-55-5.
[Prague Protein Spring Meeting 2016: Proteins and their Design /4./. 05.05.2016-08.05.2016, Praha]
Institucionální podpora: RVO:61388963
Klíčová slova: explicit-solvent molecular dynamics * quantum mechanical methods * noncovalent interactions
Kód oboru RIV: CF - Fyzikální chemie a teoretická chemie
Trvalý link: http://hdl.handle.net/11104/0260098 - 10.0455224 - ÚOCHB 2016 CZ eng A - Abstrakt
Zoll, Sebastian - Stanchev, Stancho - Began, Jakub - Škerle, Jan - Peclinovská, Lucie - Lepšík, Martin - Majer, Pavel - Stříšovský, Kvido
Structural basis of rhomboid intramembrane protease specificity and mechanism revealed by X-ray crystallographic analysis of rhomboid-substrate peptide complexes.
Prague Protein Spring Meeting 2014: Proteins and their interactions. Praha: Ústav organické chemie a biochemie AV ČR, v. v. i, 2014. s. 24. ISBN 978-80-86241-51-7.
[Prague Protein Spring Meeting 2014: Proteins and their interactions /3./. 09.05.2014-11.05.2014, Praha]
Institucionální podpora: RVO:61388963
Klíčová slova: intramembrane proteases * rhomboids
Kód oboru RIV: CE - Biochemie
Trvalý link: http://hdl.handle.net/11104/0255885