Role of Integrins in Sperm Activation and Fertilization
Abstract
:1. Introduction
2. Integrins in Mammalian Gametes
2.1. Integrins as a Part of the Oviductal Reservoir of Sperm
2.2. Integrins in the Interaction of Oviductal Fluid with Sperm
2.3. The Role of Integrins in Membrane Reorganization and Stability
2.4. Integrins in the Organization of Protein Complexes
2.5. The Role of Integrins in Gamete Fusion
2.5.1. Integrins as a Potential Secondary Receptor of Izumo1
2.5.2. Integrins as a Potential Binding Partner of SPACA6
3. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Subunit | Human Sperm | Mouse Sperm | ||
---|---|---|---|---|
Acrosome-Intact | Acrosome-Reacted | Acrosome-Intact | Acrosome-Reacted | |
α3 | mainly AC (20% P + M) [8] ES [9] | OAM + PM [10] AC + OAM [11] AA [12] | AA [10] | |
α4 | ES [9] mainly AC [8] * [13] | * [13] | ||
α5 | ES [9] PM [14] ES + M (25% P) [8] * [13] | * [13] | ||
α6 | ES [9] PAR + M (40% AC) [8] AC [15] * [13] | PAR [15] * [13] | ES + PAR [16] PM + AH + ES [10] AC + AH + ES [11] ES [12] | AH + ES [10] ES [12] |
αV | IAM [14] PAR + M [8] ES + PM + OAM + IAM [17] | IAM [14] ES + PAR + IAM + M [17] | AC + ES [18] IAM + OAM + PM + AH [17] | AC + ES [18] PAR + IAM + M [17] |
β1 | ES [9] PM [14] AC [15] | PAR [15] | ES + P [16] OAM + AA + AH + PM [10] AC + OAM [11] AP [12] | ES + IAM + whole head [10] |
β3 | PAR + M [8] | IAM [14] | AC + ES [18] | AC + ES [18] |
β4 | AC (40% ES + M) [8] | AA + AH + ES [11] ES [12] | ES [12] |
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Merc, V.; Frolikova, M.; Komrskova, K. Role of Integrins in Sperm Activation and Fertilization. Int. J. Mol. Sci. 2021, 22, 11809. https://doi.org/10.3390/ijms222111809
Merc V, Frolikova M, Komrskova K. Role of Integrins in Sperm Activation and Fertilization. International Journal of Molecular Sciences. 2021; 22(21):11809. https://doi.org/10.3390/ijms222111809
Chicago/Turabian StyleMerc, Veronika, Michaela Frolikova, and Katerina Komrskova. 2021. "Role of Integrins in Sperm Activation and Fertilization" International Journal of Molecular Sciences 22, no. 21: 11809. https://doi.org/10.3390/ijms222111809