Issue 74, 2019
From the journal:

Chemical Communications

Determination of nucleobase-pairing free energies from rotamer equilibria of 2-(methylamino)pyrimidines†

Jakub Radek Štoček,a   Kateřina Bártová,a   Lucie Čechová,a   Michal Šála,a   Ondřej Socha,a   Zlatko Janebaa  and  Martin Dračínský ORCID logo *a  

* Corresponding authors

a Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo nám. 2, 166 10, Prague, Czech Republic
E-mail: dracinsky@uochb.cas.cz

Abstract

A fast straightforward method for the determination of free energies of modified nucleobase pairing is proposed. The method is based on the nuclear magnetic resonance (NMR) spectroscopy monitoring of conformational changes of 2-(methylamino)-pyrimidines upon intermolecular binding.

Graphical abstract: Determination of nucleobase-pairing free energies from rotamer equilibria of 2-(methylamino)pyrimidines

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C9CC05513D
Article type
Communication
Submitted
17 Jul 2019
Accepted
16 Aug 2019
First published
16 Aug 2019

Chem. Commun., 2019,55, 11075-11078

Permissions

Request permissions

Determination of nucleobase-pairing free energies from rotamer equilibria of 2-(methylamino)pyrimidines

J. R. Štoček, K. Bártová, L. Čechová, M. Šála, O. Socha, Z. Janeba and M. Dračínský, Chem. Commun., 2019, 55, 11075 DOI: 10.1039/C9CC05513D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements