Abstract
Detecting vessels in retinal images is crucial for various medical applications, including diagnosing and monitoring eye diseases such as diabetic retinopathy, glaucoma, and macular degeneration. This paper presents a study on applying the U-Net architecture with a VGG-16 backbone for retinal vessel segmentation trained on patched images. As a source of training images, three well-labeled datasets, DRIVE, STARE, and CHASE DB1, were used for the training of the segmentation algorithm. We implemented the task-specific data class to further divide training images into patches, and the data augmentation techniques to increase the size of training set and to promote the model’s generalization ability. Additionally, a blending technique was employed to achieve smooth predictions by blending image patches. The experimental results highlight the effectiveness of the proposed approach in accurately detecting blood vessels in retinal images, providing promising prospects for improving ophthalmic diagnosis and treatment.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Notes
References
Abràmoff, M.D., et al.: Improved automated detection of diabetic retinopathy on a publicly available dataset through integration of deep learning. Invest. Ophthalmol. Vis. Sci. 57(13), 5200–5206 (2016)
Badar, M., Haris, M., Fatima, A.: Application of deep learning for retinal image analysis: a review. Comput. Sci. Rev. 35, 100203 (2020)
Li, H., Hsu, W., Lee, M.L., Wong, T.Y.: Automatic grading of retinal vessel caliber. IEEE Trans. Biomed. Eng. 52(7), 1352–1355 (2005)
Abdulsahib, A.A., Mahmoud, M.A., Mohammed, M.A., Rasheed, H.H., Mostafa, S.A., Maashi, M.S.: Comprehensive review of retinal blood vessel segmentation and classification techniques: intelligent solutions for green computing in medical images, current challenges, open issues, and knowledge gaps in fundus medical images. Netw. Model. Anal. Health Inf. Bioinf. 10, 1–32 (2021)
Kubicek, J., Timkovic, J., Penhaker, M., Augustynek, M., Bryjova, I., Kasik, V.: Extraction of optical disc geometrical parameters with using of active snake model with gradient directional information. In: Nguyen, N.T., Tojo, S., Nguyen, L.M., Trawiński, B. (eds.) ACIIDS 2017. LNCS (LNAI), vol. 10192, pp. 445–454. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-54430-4_43
Soomro, T.A., et al.: Deep learning models for retinal blood vessels segmentation: a review. IEEE Access 7, 71696–71717 (2019)
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: Navab, N., Hornegger, J., Wells, W.M., Frangi, A.F. (eds.) MICCAI 2015. LNCS, vol. 9351, pp. 234–241. Springer, Cham (2015). https://doi.org/10.1007/978-3-319-24574-4_28
Wang, C., Zhao, Z., Ren, Q., Yongtao, X., Yi, Yu.: Dense u-net based on patch-based learning for retinal vessel segmentation. Entropy 21(2), 168 (2019)
Simonyan, K., Zisserman, A.: Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556 (2014)
Siddique, N., Paheding, S., Elkin, C.P., Devabhaktuni, V.: U-net and its variants for medical image segmentation: a review of theory and applications. IEEE Access 9, 82031–82057 (2021)
Staal, J., Abràmoff, M.D., Niemeijer, M., Viergever, M.A., Van Ginneken, B.: Ridge-based vessel segmentation in color images of the retina. IEEE Trans. Med. Imaging 23(4), 501–509 (2004)
Hoover, A.D., Kouznetsova, V., Goldbaum, M.: Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response. IEEE Trans. Med. Imaging 19(3), 203–210 (2000)
Owen, C.G., et al.: Measuring retinal vessel tortuosity in 10-year-old children: validation of the computer-assisted image analysis of the retina (CAIAR) program. Invest. Ophthalmol. Vis. Sci. 50(5), 2004–2010 (2009)
Lin, T.Y., Goyal, P., Girshick, R., He, K., Dollár, P.: Focal loss for dense object detection. In: Proceedings of the IEEE International Conference on Computer Vision, pp. 2980–2988 (2017)
Hasal, M., Nowaková, J., Hernández-Sosa, D., Timkovič, J.: Image enhancement in retinopathy of prematurity. In: Barolli, L., Miwa, H. (eds.) INCoS 2022. Lecture Notes in Networks and Systems, vol. 527, pp. 422–431. Springer, Cham (2022). https://doi.org/10.1007/978-3-031-14627-5_43
Kukil: Intersection over union (IoU) in object detection & segmentation. Web-Site (2022)
Lemaître, G., Nogueira, F., Aridas, C.K.: Imbalanced-learn: a Python toolbox to tackle the curse of imbalanced datasets in machine learning. J. Mach. Learn. Res. 18(17), 1–5 (2017)
Liskowski, P., Krawiec, K.: Segmenting retinal blood vessels with deep neural networks. IEEE Trans. Med. Imaging 35(11), 2369–2380 (2016)
Mo, J., Zhang, L.: Multi-level deep supervised networks for retinal vessel segmentation. Int. J. Comput. Assist. Radiol. Surg. 12, 2181–2193 (2017)
Vooban AI: Satellite image segmentation: a workflow with u-net. Web-Site (2017)
Acknowledgements
This work was supported by the European Regional Development Fund under the project AI &Reasoning (reg. no. CZ.02.1.01/0.0/0.0/15_003/0000466), and by the project of the Student Grant System, VSB – Technical University of Ostrava, Czech Republic, under the grant No. SP2023/12” Parallel processing of Big Data IX and by the project Constrained multi-objective Optimization Based on Problem Landscape Analysis funded by the Czech Science Foundation (grant no. GF22-34873K).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Hasal, M., Pecha, M., Nowaková, J., Hernández-Sosa, D., Snášel, V., Timkovič, J. (2023). Retinal Vessel Segmentation by U-Net with VGG-16 Backbone on Patched Images with Smooth Blending. In: Barolli, L. (eds) Advances in Intelligent Networking and Collaborative Systems. INCoS 2023. Lecture Notes on Data Engineering and Communications Technologies, vol 182. Springer, Cham. https://doi.org/10.1007/978-3-031-40971-4_44
Download citation
DOI: https://doi.org/10.1007/978-3-031-40971-4_44
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-031-40970-7
Online ISBN: 978-3-031-40971-4
eBook Packages: Intelligent Technologies and RoboticsIntelligent Technologies and Robotics (R0)