Abstract
Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host.
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Abbreviations
- Arg:
-
Arginase
- Arm:
-
Armstrong
- ATRA:
-
All-trans retinoic acid
- B. fragilis :
-
Bacteroides fragilis
- C. albicans :
-
Candida albicans
- C13:
-
Clone 13
- CCR:
-
C-C Chemokine receptor
- COST:
-
European Cooperation in Science and Technology
- EBV:
-
Epstein Barr virus
- ETBF:
-
Enterotoxigenic Bacteroides fragilis
- FV:
-
Friend virus
- H. felis:
-
Helicobacter felis
- H. polygyrus :
-
Heligmosomoides polygyrus
- HbsAg:
-
HBV surface antigen
- HDT:
-
Host-directed therapy
- IAV:
-
Influenza A virus
- iNKT:
-
Invariant NK T
- JEV:
-
Japanese encephalitis virus
- K. pneumoniae:
-
Klebsiella pneumoniae
- L. major :
-
Leishmania major
- LCMV:
-
Lymphocytic choriomeningitis virus
- LOX:
-
Lipoxygenase
- Mφ:
-
Macrophage
- M-MDSC:
-
Monocytic MDSC
- M. tuberculosis:
-
Mycobacterium tuberculosis
- MR:
-
Mannose receptor
- MRC:
-
Myeloid regulatory cell
- mTOR:
-
Mammalian target of rapamycin
- NADPH:
-
Nicotinamide adenine dinucleotide phosphate
- NOS:
-
NO synthase
- P. aeruginosa:
-
Pseudomonas aeruginosa
- PcP:
-
Pneumocystis pneumonia
- PDE:
-
Phosphodiesterase
- PGE2:
-
Prostaglandin E2
- PMN-MDSC:
-
Neutrophil-like MDSC
- ROS:
-
Reactive oxygen species
- S. aureus :
-
Staphylococcus aureus
- SIV:
-
Simian immunodeficiency virus
- T. crassiceps :
-
Taenia crassiceps
- T. cruzi :
-
Trypanosoma cruzi
- T. gondii :
-
Toxoplasma gondii
- TB:
-
Tuberculosis
- Tfh:
-
T Follicular helper
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Acknowledgements
We thank Ronnie Grant (University of Edinburgh) for figure editing.
Funding
This work was supported by European Cooperation in Science and Technology (COST) and the COST Action BM1404 Mye-EUNITER (http://www.mye-euniter.eu). COST is part of the European Union Framework Programme Horizon 2020. Estibaliz Glaría is supported by a fellowship from the University of Barcelona (Ajuts de Personal Investigador predoctoral en Formació, APIF); Thalia Garcia-Tellez is supported by the Institut Carnot Pasteur Maladie Infectieuses (ANR 11-CARN 017-01) as part of the Pasteur—Paris University (PPU) International PhD Program and by Sidaction.
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Conceptualization and writing of the original draft: all authors. Figure design: AD, EG, TG-T, and AFV. Revisions and editing: AD, NEN, CG, and AFV. Supervision: AD and AFV. All authors approved the final version of this paper.
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Dorhoi, A., Glaría, E., Garcia-Tellez, T. et al. MDSCs in infectious diseases: regulation, roles, and readjustment. Cancer Immunol Immunother 68, 673–685 (2019). https://doi.org/10.1007/s00262-018-2277-y
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DOI: https://doi.org/10.1007/s00262-018-2277-y