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Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus

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Abstract

The yeast Magnusiomyces capitatus is an opportunistic human pathogen causing rare yet severe infections, especially in patients with hematological malignancies. Here, we report the 20.2 megabase genome sequence of an environmental strain of this species as well as the genome sequences of eight additional isolates from human and animal sources providing an insight into intraspecies variation. The distribution of single-nucleotide variants is indicative of genetic recombination events, supporting evidence for sexual reproduction in this heterothallic yeast. Using RNAseq-aided annotation, we identified genes for 6518 proteins including several expanded families such as kexin proteases and Hsp70 molecular chaperones. Several of these families are potentially associated with the ability of M. capitatus to infect and colonize humans. For the purpose of comparative analysis, we also determined the genome sequence of a closely related yeast, Magnusiomyces ingens. The genome sequences of M. capitatus and M. ingens exhibit many distinct features and represent a basis for further comparative and functional studies.

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Acknowledgements

We would like to thank Cletus P. Kurtzman, James Swezey (Agricultural Research Service, Peoria, IL, USA), Dominika Tanušková, and Alexandra Kolenová (University Hospital, Bratislava, Slovakia) for providing us with the yeast strains.

Funding

This research was supported by grants from the Slovak Research and Development Agency [APVV-14-0253 (JN), APVV-15-0022 (LT)], the Slovak Grant Agency [VEGA 1/0458/18 (TV), VEGA 1/0333/15 (JN), VEGA 1/0052/16 (LT), VEGA 1/0684/16 (BB)], the Comenius University grants [UK/282/2018 (HL), UK/268/2018 (VH), UK/208/2018 (LZ)], the Faculty of Medicine and Dentistry, Palacký University Olomouc [IGA_LF_2017_031 and RVO 61989592 (VR)], and NSERC Canada [RGPIN-2017-05411 (BFL)].

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  1. Faculty of Mathematics, Physics, and Informatics, Comenius University in Bratislava, Bratislava, Slovakia

    Bronislava Brejová, Andrej Baláž & Tomáš Vinař

  2. Faculty of Natural Sciences, Comenius University in Bratislava, Bratislava, Slovakia

    Hana Lichancová, Filip Brázdovič, Eva Hegedűsová, Michaela Forgáčová Jakúbková, Viktória Hodorová, Vladimíra Džugasová, Lucia Zeiselová, Andrea Cillingová, Martina Neboháčová, Ľubomír Tomáška & Jozef Nosek

  3. Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic

    Vladislav Raclavský

  4. Robert Cedergren Centre for Bioinformatics and Genomics, Université de Montréal, Montréal, QC, Canada

    B. Franz Lang

  5. Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czech Republic

    Eva Hegedűsová

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Correspondence to Bronislava Brejová or Jozef Nosek.

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Additional information

Communicated by M. Kupiec.

The reported nucleotide sequence data are available in DDBJ/EMBL/GenBank under Bioprojects, with Accession Numbers PRJEB27745, PRJEB27746.

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Brejová, B., Lichancová, H., Brázdovič, F. et al. Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus. Curr Genet 65, 539–560 (2019). https://doi.org/10.1007/s00294-018-0904-y

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