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Surface plasmon resonance biosensor for the ultrasensitive detection of bisphenol A

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Abstract

Bisphenol A (BpA) is a chemical that is extensively used in common plastic products, such as food and drink containers. It can leach from the plastics and penetrate into the human body, where it acts as an endocrine disruptor with significant risks to human health. In order to minimize the exposure of human populations to BpA, methods for the detection of BpA are needed. In this work, we present a novel surface plasmon resonance (SPR) biosensor for ultrasensitive detection of BpA. Our approach combines a binding inhibition assay with functionalized gold nanoparticles for the enhancement of sensor response. We demonstrate that the developed biosensor enables the detection of BpA in a wide range of concentrations (0.01 to 100,000 ng/mL) with an extremely low limit of detection—5.2 pg/mL.

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Funding

Research into functional nanoparticles used in this study was in part supported by the Ministry of Health of the Czech Republic, grant no. 16-27611A.

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Authors and Affiliations

  1. Institute of Photonics and Electronics, Czech Academy of Sciences, Chaberská 57, 182 51, Prague, Czech Republic

    Chadtová Song Xue, Gedeonová Erika & Homola Jiří

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  1. Chadtová Song Xue
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  2. Gedeonová Erika
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  3. Homola Jiří
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Correspondence to Homola Jiří.

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This study did not involve any human participants or animals.

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The authors declare that they have no conflict of interest.

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Xue, C.S., Erika, G. & Jiří, H. Surface plasmon resonance biosensor for the ultrasensitive detection of bisphenol A. Anal Bioanal Chem 411, 5655–5658 (2019). https://doi.org/10.1007/s00216-019-01996-8

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  • DOI: https://doi.org/10.1007/s00216-019-01996-8

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