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Sex Differences in Heart Disease pp 257–265Cite as

Cardiac Mitochondria and Ischemia/Reperfusion Injury—Sex Differences

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Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 21))

Abstract

It is now widely accepted that function of cardiac mitochondria is sex-dependent. Female mitochondria better utilize lipids and exhibit higher oxidative capacity in comparison with males. Our results have revealed that female cardiac mitochondria are more resistant to calcium–induced swelling as compared with the male myocardium; this suggests their better protection against mitochondrial permeability transition pore (PTP) opening. It seems to us that sex-dependent specificity of the PTP function is not the result of differences in its protein composition, since the male and female rat heart contains comparable amount of ATP synthase and its regulatory protein cyclophilinD (CypD). The higher hypoxic tolerance of the female cardiac mitochondria thus rather reflects sex differences in the regulation of PTP function, probably together with regulation of CypD by post-translational modifications. The precise knowledge of the composition of the PTP complex and regulation of pore opening are essential conditions for the development of new drugs targeting the function of PTP.

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Acknowledgments

The work was supported by Czech Science Foundation No 19-04790Y.

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Authors and Affiliations

  1. Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic

    Zdenek Drahota, Marketa Hlavackova & Bohuslav Ostadal

Authors
  1. Zdenek Drahota
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  2. Marketa Hlavackova
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  3. Bohuslav Ostadal
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Corresponding author

Correspondence to Bohuslav Ostadal .

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Editors and Affiliations

  1. Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic

    Bohuslav Ostadal

  2. St. Boniface Hospital Albrechtsen Research Centre, Institute of Cardiovascular Sciences, Winnipeg, MB, Canada

    Naranjan S. Dhalla

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Drahota, Z., Hlavackova, M., Ostadal, B. (2020). Cardiac Mitochondria and Ischemia/Reperfusion Injury—Sex Differences. In: Ostadal, B., Dhalla, N.S. (eds) Sex Differences in Heart Disease. Advances in Biochemistry in Health and Disease, vol 21. Springer, Cham. https://doi.org/10.1007/978-3-030-58677-5_15

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