We study the Oseen problem with rotational effect in exterior three-dimensional domains. Using a variational approach we prove existence and uniqueness theorems in anisotropically weighted Sobolev spaces in the whole three-dimensional space. As the main tool we derive and apply an inequality of the Friedrichs-Poincaré type and the theory of Calderon-Zygmund kernels in weighted spaces. For the extension of results to the case of exterior domains we use a localization procedure.