Issue 82, 2019
From the journal:

Chemical Communications

Nitrobenzyl-based fluorescent photocages for spatial and temporal control of signalling lipids in cells†

Pankaj Gaur,‡a   Oleksandr A. Kucherak,‡a   Yulia G. Ermakova,b   Volodymyr V. Shvadchaka  and  Dmytro A. Yushchenko ORCID logo *ac  

* Corresponding authors

a Laboratory of Chemical Biology, The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo namesti 2, 16610 Prague 6, Czech Republic
E-mail: yushchenko@uochb.cas.cz

b Cell Biology & Biophysics Unit, European Molecular Biology Laboratory (EMBL), Meyerhofstrasse 1, 69117 Heidelberg, Germany

c Group of Bioconjugation Chemistry, Miltenyi Biotec GmbH, Friedrich-Ebert-Straße 68, 51429 Bergisch Gladbach, Germany
E-mail: dmytroy@miltenyibiotec.de

Abstract

Here we present a set of fluorescent cages prepared by tethering fluorescent dyes to a photolabile group. The developed molecules enable caging of signalling lipids, their delivery to specific cellular membranes, with further imaging, quantification, and controlled photorelease of active lipids in living cells.

Graphical abstract: Nitrobenzyl-based fluorescent photocages for spatial and temporal control of signalling lipids in cells

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Article information

DOI
https://doi.org/10.1039/C9CC05602E
Article type
Communication
Submitted
19 Jul 2019
Accepted
27 Aug 2019
First published
16 Sep 2019
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2019,55, 12288-12291

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Nitrobenzyl-based fluorescent photocages for spatial and temporal control of signalling lipids in cells

P. Gaur, O. A. Kucherak, Y. G. Ermakova, V. V. Shvadchak and D. A. Yushchenko, Chem. Commun., 2019, 55, 12288 DOI: 10.1039/C9CC05602E

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