Skip to main content
SpringerLink
Log in

Polylactide/polyethylene glycol fibrous mats for local paclitaxel delivery: comparison of drug release into liquid medium and to HEMA-based hydrogel model

  • Original Paper
  • Published:
Monatshefte für Chemie - Chemical Monthly Aims and scope Submit manuscript

Abstract

2-Hydroxyethyl methacrylate (HEMA) hydrogels containing 37% water were prepared to investigate the release of hydrophobic anticancer drug paclitaxel (PTX) from electrospun polylactide (PLA) fibrous mats. The impact of the incorporated amphiphilic polyethylene glycol (PEG) on the drug release was also studied. The release profiles were investigated in various arrangements and compared to release into aqueous media. The nanofibers with added PEG released significantly higher amounts of paclitaxel and for longer time period compared to fibers containing only the hydrophobic drug. When compared various release conditions, significantly higher amount of paclitaxel released to hydrogel compared to aqueous media. HEMA-based hydrogel was found to better approximate in vivo conditions in comparison with commonly used liquid media.

Graphic abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Singla AK, Garg A, Aggarwal D (2002) Int J Pharm 235:179

    Article  CAS  PubMed  Google Scholar 

  2. Krukiewicz K, Zak JK (2016) Mater Sci Eng C Mater Biol Appl 62:927

    Article  CAS  PubMed  Google Scholar 

  3. Polakova L, Sirc J, Hobzova R, Cocarta AI, Hermankova E (2019) Int J Pharm 558:268

    Article  CAS  PubMed  Google Scholar 

  4. Elstad NL, Fowers KD (2009) Adv Drug Deliv Rev 61:785

    Article  CAS  PubMed  Google Scholar 

  5. Ding Q, Li Z, Yang Y, Guo G, Luo F, Chen Z, Yang Y, Qian Z, Shi S (2016) Drug Deliv 23:2677

    Article  CAS  PubMed  Google Scholar 

  6. Ma G, Liu Y, Peng C, Fang D, He B, Nie J (2011) Carbohydr Polym 86:505

    Article  CAS  Google Scholar 

  7. Ranganath SH, Wang CH (2008) Biomaterials 29:2996

    Article  CAS  PubMed  Google Scholar 

  8. Hrib J, Sirc J, Hobzova R, Hampejsova Z, Bosakova Z, Munzarova M, Michalek J (2015) Beilstein J Nanotechnol 6:1939

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Wang X, Venkatraman SS, Boey FYC, Loo JS, Tan LP (2006) Biomaterials 27:5588

    Article  CAS  PubMed  Google Scholar 

  10. Sirc J, Hampejsova Z, Trnovska J, Kozlik P, Hrib J, Hobzova R, Zajicova A, Holan V, Bosakova Z (2017) Pharm Res 34:1391

    Article  CAS  PubMed  Google Scholar 

  11. Tan LP, Venkatraman SS, Sung PF, Wang XT (2004) Int J Pharm 283:89

    Article  CAS  PubMed  Google Scholar 

  12. Huang CL, Steele TWJ, Widjaja E, Boey FYC, Venkatraman SS, Loo JSC (2013) NPG Asia Mater 5:e54

    Article  CAS  Google Scholar 

  13. Steele TW, Huang CL, Widjaja E, Boey FY, Loo JS, Venkatraman SS (2011) Acta Biomater 7:1973

    Article  CAS  PubMed  Google Scholar 

  14. Hobzova R, Hampejsova Z, Cerna T, Hrabeta J, Venclikova K, Jedelska J, Bakowsky U, Bosakova Z, Lhotka M, Vaculin S, Franek M, Steinhart M, Kovarova J, Michalek J, Sirc J (2019) Mater Sci Eng C Mater Biol Appl 98:982

    Article  CAS  PubMed  Google Scholar 

  15. Plch J, Venclikova K, Janouskova O, Hrabeta J, Eckschlager T, Kopeckova K, Hampejsova Z, Bosakova Z, Sirc J, Hobzova R (2018) Macromol Biosci 18:e1800011

    Article  CAS  PubMed  Google Scholar 

  16. Tredan O, Galmarini CM, Patel K, Tannock IF (2007) J Natl Cancer Inst 99:1441

    Article  CAS  PubMed  Google Scholar 

  17. Ronnov-Jessen L, Petersen OW, Bissell MJ (1996) Physiol Rev 76:69

    Article  CAS  PubMed  Google Scholar 

  18. Huijbers IJ, Iravani M, Popov S, Robertson D, Al-Sarraj S, Jones C, Isacke CM (2010) PLoS ONE 5:e9808

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK (2001) Proc Natl Acad Sci USA 98:4628

    Article  CAS  PubMed  Google Scholar 

  20. Liang S, Xu J, Weng L, Dai H, Zhang X, Zhang L (2006) J Control Release 115:189

    Article  CAS  PubMed  Google Scholar 

  21. McCabe M (1972) Biochem J 127:249

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Blakney AK, Little AB, Jiang Y, Woodrow KA (2016) Drug Deliv 24:582

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Liu P, De Wulf O, Laru J, Heikkila T, van Veen B, Kiesvaara J, Hirvonen J, Peltonen L, Laaksonen T (2013) AAPS PharmSciTech 14:748

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Bevernage J, Brouwers J, Brewster ME, Augustijns P (2013) Int J Pharm 453:25

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We are grateful to Nanovia Ltd. for cooperation in fiber preparation by needleless electrospinning and to the Grant Agency of the Czech Republic [project number 16-04863S] and the Charles University [project number SVV260440], the Ministry of Education, Youth and Sports of the Czech Republic within the National Sustainability Program II [project BIOCEV-FAR LQ1604, “BIOCEV” CZ.1.05/1.1.00/02.0109] for financial support.

Author information

Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Science, Charles University, Prague, Czech Republic

    Zuzana Hampejsova, Jan Batek & Zuzana Bosakova

  2. Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

    Jakub Sirc & Radka Hobzova

Authors
  1. Zuzana Hampejsova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jan Batek
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jakub Sirc
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Radka Hobzova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zuzana Bosakova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zuzana Bosakova.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hampejsova, Z., Batek, J., Sirc, J. et al. Polylactide/polyethylene glycol fibrous mats for local paclitaxel delivery: comparison of drug release into liquid medium and to HEMA-based hydrogel model. Monatsh Chem 150, 1691–1696 (2019). https://doi.org/10.1007/s00706-019-02469-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00706-019-02469-5

Keywords

Search

Navigation