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PARV4 found in wild chimpanzee faeces: an alternate route of transmission?

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Abstract

Human parvovirus 4 (PARV4, family Parvoviridae, genus Tetraparvovirus) displays puzzling features, such as uncertain clinical importance/significance, unclear routes of transmission, and discontinuous geographical distribution. The origin, or the general reservoir, of human PARV4 infection is unknown. We aimed to detect and characterize PARV4 virus in faecal samples collected from two wild chimpanzee populations and 19 species of captive non-human primates. We aimed to investigate these species as a potential reservoir and alternate route of transmission on the African continent. From almost 500 samples screened, a single wild Pan troglodytes schweinfurthii sample tested positive. Full genome analysis, as well as single ORF phylogenies, confirmed species-specific PARV4 infection.

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Acknowledgements

We thank the Tanzanian Wildlife Research Institute (TAWIRI) and Tanzanian Commission for Science and Technology (COSTECH) for permission to conduct research in Tanzania. This research was carried out under the project CEITEC 2020 (LQ1601) with financial support from the Ministry of Education, Youth and Sports of the Czech Republic under the National Program of Sustainability II, by project LO1218 with financial support from the Ministry of Education, Youth and Sports of the Czech Republic under the NPU I program, and further co-financed from the European Social Fund and the state budget of the Czech Republic (project OPVK CZ.1.07/2.3.00/20.0300). We acknowledge a grant for the development of research organization (RVO: RO0516). Support for GMERC (formerly UPP) and ongoing work at Issa comes from the UCSD/Salk Center for Academic Research and Training in Anthropogeny (CARTA).

Funding

All grants funding this study are listed in the Acknowledgments section.

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Authors and Affiliations

  1. Department of Infectious Diseases and Microbiology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, 612 42, Brno, Czech Republic

    Kristýna Brožová, Eva Dadáková & Vladimír Celer

  2. Department of Pathological Morphology and Parasitology, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, 612 42, Brno, Czech Republic

    David Modrý & Mwanahamisi I. Mapua

  3. Biology Centre, Institute of Parasitology, Czech Academy of Sciences, Branišovská 31, 370 05, České Budějovice, Czech Republic

    David Modrý

  4. CEITEC-VFU, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, 612 42, Brno, Czech Republic

    David Modrý & Kristýna Hrazdilová

  5. School of Natural Sciences and Psychology, Liverpool John Moores University, Byrom Street, Liverpool, L33AF, UK

    Alex K. Piel & Fiona A. Stewart

  6. Greater Mahale Ecosystem Research and Conservation Project (GMERC), Dar es Salaam, Tanzania

    Alex K. Piel & Fiona A. Stewart

  7. Department of Virology, Veterinary Research Institute, Hudcova 296/70, 621 00, Brno, Czech Republic

    Kristýna Hrazdilová

Authors
  1. Kristýna Brožová
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  2. David Modrý
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  3. Eva Dadáková
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  4. Mwanahamisi I. Mapua
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  5. Alex K. Piel
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  6. Fiona A. Stewart
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  7. Vladimír Celer
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  8. Kristýna Hrazdilová
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Correspondence to Kristýna Hrazdilová.

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Brožová, K., Modrý, D., Dadáková, E. et al. PARV4 found in wild chimpanzee faeces: an alternate route of transmission?. Arch Virol 164, 573–578 (2019). https://doi.org/10.1007/s00705-018-4073-6

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  • DOI: https://doi.org/10.1007/s00705-018-4073-6

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