Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014, 158(2):221-226 | DOI: 10.5507/bp.2012.076

Endovascular brain intervention and mapping in a dog experimental model using magnetically-guided micro-catheter technology

Tomas Karaa,b, Pavel Leinvebera, Michal Vlasinc, Pavel Juraka,d, Miroslav Novaka, Zdenek Novake, Jan Chrastinae, Krzysztof Czechowicza, Milos Belehrada, Samuel J. Asirvathamb
a International Clinical Research Center - Department of Cardiovascular Diseases, St Anne's University Hospital in Brno and Masaryk University, Brno, Czech Republic
b Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA
c School of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Brno
d Institute of Scientific Instruments of the Czech Academy of Sciences, Brno
e Department of Neurosurgery, St Anne's University Hospital in Brno and Masaryk University, Brno

Aim: Despite the substantial progress that has been achieved in interventional cardiology and cardiac electrophysiology, endovascular intervention for the diagnosis and treatment of central nervous system (CNS) disorders such as stroke, epilepsy and CNS malignancy is still limited, particularly due to highly tortuous nature of the cerebral arterial and venous system. Existing interventional devices and techniques enable only limited and complicated access especially into intra-cerebral vessels. The aim of this study was to develop a micro-catheter magnetically-guided technology specifically designed for endovascular intervention and mapping in deep CNS vascular structures.

Methods: Mapping of electrical brain activity was performed via the venous system on an animal dog model with the support of the NIOBE II system.

Results: A novel micro-catheter specially designed for endovascular interventions in the CNS, with the support of the NIOBE II technology, was able to reach safely deep intra-cerebral venous structures and map the electrical activity there. Such structures are not currently accessible using standard catheters.

Conclusion: This is the first study demonstrating successful use of a new micro-catheter in combination with NIOBE II technology for endovascular intervention in the brain.

Keywords: central nervous system, magnetically-guided endovascular interventions, mapping, NIOBE

Received: June 25, 2012; Accepted: July 19, 2012; Prepublished online: November 12, 2012; Published: June 23, 2014  Show citation

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Kara, T., Leinveber, P., Vlasin, M., Jurak, P., Novak, M., Novak, Z., ... Asirvatham, S.J. (2014). Endovascular brain intervention and mapping in a dog experimental model using magnetically-guided micro-catheter technology. Biomedical papers, 158(2), 221-226. doi: 10.5507/bp.2012.076
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